RecruitingNCT03067467

Metabolic Characteristics of Brain Tumors Using Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopic Imaging (MRSI)

Investigating Metabolic Characteristics of Intracranial Malignancy In Vivo Using Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopic Imaging (MRSI)


Sponsor

University of Texas Southwestern Medical Center

Enrollment

25 participants

Start Date

Jun 1, 2019

Study Type

OBSERVATIONAL

Conditions

Summary

This is a non-randomized, purely observational, feasibility study to detect metabolic changes in patients with brain malignancy using a novel hyperpolarized \[1-13C\]pyruvate MRSI.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study uses a special type of MRI scan with a carbon-13 tracer to measure how brain tumor cells use energy (metabolism), which can help doctors better distinguish tumors from normal brain tissue and monitor how well treatment is working. **You may be eligible if...** - You are between 18 and 70 years old - You have been diagnosed with a brain tumor (such as glioma, meningioma, or brain metastases) confirmed by imaging - You have not yet started chemotherapy or radiation therapy for this tumor - You are able to read and speak English - Women of childbearing age must agree to use contraception **You may NOT be eligible if...** - You are currently enrolled in another experimental study - You have previously received radiation or chemotherapy for a brain tumor - You have uncontrolled chronic diseases (such as high blood pressure, diabetes, heart failure, or active infection) - You have a history of alcohol abuse or illicit drug use - You are pregnant or breastfeeding - You have conditions that prevent MRI scanning (such as a pacemaker, certain implants, severe claustrophobia, or serious kidney disease) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGHyperpolarized 13C-Pyruvate

Hyperpolarized 13C-pyruvate IV bolus followed by brain MRSI.

DRUGGadolinium

Brain MRI performed with and without gadolinium-based contrast.


Locations(1)

UT Southwestern Medical Center

Dallas, Texas, United States

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NCT03067467


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