Hyperandrogenemia and Altered Day-night LH Pulse Patterns

This study investigates whether excess male hormones (androgens) in teenage girls disrupt the normal 24-hour rhythm of a key reproductive hormone (LH — luteinizing hormone), which could help explain why some girls develop irregular periods and hormonal imbalances leading to Polycystic Ovary Syndrome (PCOS). **You may be eligible if...** - You are a mid-to-late pubescent adolescent girl (at least Tanner breast stage 3, but no more than 2 years past your first period) - You have elevated male hormone levels or clear signs of excess body/facial hair (hirsutism) - You are in generally good health - You are willing to avoid pregnancy using reliable non-hormonal methods during the study **You may NOT be eligible if...** - You are male - You have a known hormonal condition (other than PCOS) causing your symptoms, such as adrenal or ovarian tumors, or congenital adrenal hyperplasia - You have diabetes or significantly abnormal blood sugar - You are pregnant or currently breastfeeding - You have a significant heart, lung, or kidney condition - You have a personal history of breast, ovarian, or uterine cancer - You have taken hormonal medications, diabetes drugs, or blood pressure medications within the past 2–3 months - Your body weight is below the 5th percentile for your age (underweight) or under 25 kg Talk to your doctor to see if this trial is right for you.