RecruitingNCT03225677

Novel Tracer Methods to Evaluate Muscle Protein Metabolism in Cirrhosis

Multiple Tracer Using Single Muscle Biopsy Technique in Evaluating Protein Synthesis and Break Down in Muscles of Cirrhotic Patients

Sponsor

The Cleveland Clinic

Enrollment

20 participants

Start Date

Aug 3, 2017

Study Type

OBSERVATIONAL

Conditions

Cirrhosis

Summary

To determine the rate and mechanisms of skeletal muscle protein synthesis and breakdown in cirrhotic patients by using multiple tracers and single muscle biopsies.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

The diagnosis of cirrhosis based on liver biopsy and/or clinical, biochemical, and imaging criteria.
Patients with Child Pugh score from A5- to B7
Control group: Subject in control group should have serum ALT and AST within normal range.

Exclusion Criteria7

diabetes
cancer
kidney failure
pregnancy
recent surgery (bowel resection or Gastric bypass operation)
Advanced cardiac or pulmonary disease
patient with thyroid disease \& Coagulopathy ( INR >1.4 and platelet count <80,000/ml)

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Interventions

PROCEDUREblood draw and muscle biopsy

One venous catheter will be used for bolus injection of multiple labeled AA at the beginning .The second venous catheter will inserted in the other arm for 5 ml of arterialized venous blood draw.Following the infusions, a single muscle biopsy will be performed from the vastus lateralis of the thigh using the Bergstromm needle.