RecruitingNCT06345547

Muscle Mass Via UltraSound in Cirrhosis (MMUSCLE)

Prospective Observational Cohort Survey to Assess the Prevalence and Development of Sarcopenia and the Correlation of Muscle Mass and Outcome in Patients With Cirrhosis by Skeletal Muscle Ultrasound.

Sponsor

University Hospital, Antwerp

Enrollment

60 participants

Start Date

May 6, 2024

Study Type

OBSERVATIONAL

Conditions

Sarcopenia Cirrhosis Malnutrition

Summary

The goal of this observational cohort study is to learn about loss of muscle mass and muscle strength (sarcopenia) in patients with cirrhosis. The main question\[s\] it aims to answer are: * what is the prevalence and development of sarcopenia in cirrhosis? * what is the role of malnutrition? Participants will * undergo a muscle ultrasound of the lower and upper limb muscles * handgrip strength will be measured * malnutrition screening and assessment * complete a questionnaire to assess quality of life

Eligibility

Min Age: 18 Years

Inclusion Criteria1

diagnosis of cirrhosis and follow-up in the University Hospital of Antwerp

Exclusion Criteria3

known patient will against participation in the study or against the measures applied in the study
a decision made prior to inclusion to stop further treatment of the patient within the next 24 hours
no complete remission of malignancy including hepatocellular carcinoma within the past 12 months

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Interventions

OTHERultrasound

Ultrasound of m. quadriceps and m. thenar All ultrasound measurements will be performed in triplicate, with the average of the scores used in final analyses. Four parameters will be evaluated: muscle thickness, muscle cross sectional area, pennation angle and echo intensity (gain, depth and frequency will be kept constant). Hand grip strength measurement: measurement by an electronic hand dynamometer DynEx1TM (MD Systems, Inc. Ohio, USA). The recommendations for the handgrip strength test of the American Society of Hand Therapists will be followed: The maximum of the three values will be considered for analysis.