RecruitingNCT03313024

Berlin-Brandenburg Pregnancy Cohort

Characterization of Immune Cell-trophoblast-interaction in Pregnancy Disorders

Sponsor

Charite University, Berlin, Germany

Enrollment

1,580 participants

Start Date

Sep 26, 2017

Study Type

OBSERVATIONAL

Conditions

Pregnancy Complications Preeclampsia Diabetes Mellitus in Pregnancy

Summary

This study will investigate the interplay of different immune cells and placental cells as well as their potential for the development of pregnancy complications. In particular, the translation of the uteroplacental syndrome into a maternal syndrome, considered in the multifactorial pregnancy disorder preeclampsia, will be investigated. Immune cell subtypes are causally involved in the formation and translation of preeclampsia by inducing an endothelial dysfunction which leads to cardiovascular damage.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 45 Years

Plain Language Summary

Simplified for easier understanding

This pregnancy study based in Berlin and Brandenburg, Germany, is following both healthy pregnant women and those with pregnancy-related complications to better understand what biological factors affect pregnancy outcomes. **You may be eligible if...** - You are pregnant and willing to give informed consent - You are healthy, OR you have been diagnosed with preeclampsia (high blood pressure in pregnancy), gestational hypertension, or gestational diabetes **You may NOT be eligible if...** - You have an active infection during pregnancy - You have a history of alcohol or drug abuse - You have a chronic or ongoing medical condition Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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