RecruitingNot ApplicableNCT03527420

DNA Methylation and Vascular Function

DNA Methylation and Vascular Function in Obesity: Role of Exercise and Weight Loss

Sponsor

University of Illinois at Chicago

Enrollment

80 participants

Start Date

Oct 11, 2019

Study Type

INTERVENTIONAL

Conditions

Vascular Dysfunction Obesity

Summary

The main objective is to examine DNA hypomethylation as an underlying mechanism for the increased production of inflammatory cytokines and the impaired vascular function in obese individuals and as a potential target for nonpharmacological preventive/therapeutic interventions such as aerobic exercise.

Eligibility

Min Age: 18 YearsMax Age: 50 Years

Inclusion Criteria4

BMI ≥ 35 kg/m2
Between ages 18-50 years
Not pregnant
Approved for a bariatric surgery

Exclusion Criteria4

To avoid confounding from other inflammatory conditions individuals with current cancer, heart, kidney or liver disease, gallbladder disease or acute or chronic inflammatory diseases (including rheumatoid arthritis, lupus and other autoimmune diseases and genetic diseases) will be excluded
Pregnant women will be excluded, as they will not be eligible for bariatric surgery
Current smokers
Currently abusing alcohol or drugs

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