RecruitingNCT03535376

Bariatric Surgery and Pharmacokinetics of Valsartan

Bariatric Surgery and Pharmacokinetics of Valsartan: BAR-MEDS Valsartan


Sponsor

Norwegian University of Science and Technology

Enrollment

12 participants

Start Date

Nov 2, 2016

Study Type

OBSERVATIONAL

Conditions

Summary

Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines. These factors are potentially influenced by bariatric surgery. Little is so far known about how gastric bypass and sleeve gastrectomy impacts the biological availability of medication. In this study the pharmacokinetic effects of bariatric surgery on valsartan are investigated.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study examines how bariatric surgery — specifically gastric bypass or sleeve gastrectomy — affects the way the body absorbs the blood pressure medication valsartan. Surgery changes the digestive system in ways that can alter how medications are processed, and this study aims to understand those changes to improve medication management after surgery. Norwegian citizens who are scheduled to undergo gastric bypass or sleeve gastrectomy in Central Norway may be eligible, while those who have previously had surgery on their gastrointestinal tract are excluded. Participation involves taking valsartan and providing blood samples before and after surgery to measure how the drug is absorbed and processed by the body. This summary was generated with AI assistance to help patients understand the study in plain language.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGValsartan

Patients are tested for their normal prescription valsartan medication


Locations(1)

St. Olavs University Hospital

Trondheim, Norway

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NCT03535376


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