The Taste-Mood Diagnostic Study

This trial is investigating whether changes in a person's sense of taste can help doctors identify and track different subtypes of depression, and whether taste response can predict how well someone will respond to antidepressant medication. **You may be eligible if...** - You have been diagnosed with Major Depressive Disorder (MDD) that has not yet been treated, or you are starting a new episode of depression without current medication - You have stopped any previous antidepressants at least 3 months ago (if applicable) - You are willing and able to participate in taste tests and follow-up visits **You may NOT be eligible if...** - You are currently taking antidepressants or other psychiatric medications - You have significant physical health conditions that could affect the study - You have taste or smell disorders unrelated to depression - You are pregnant or breastfeeding - You are unable to give informed consent Talk to your doctor to see if this trial is right for you.