Add-on Buprenorphine at Analgesic Doses for the Treatment of Severe Suicidal Ideas During a Major Depressive Episode

This trial is studying whether adding low doses of buprenorphine — a medication typically used for pain and opioid treatment — can quickly reduce severe suicidal thoughts in people hospitalized during a major depressive episode. **You may be eligible if...** - You are between 18 and 65 years old - You are currently hospitalized because of a major depressive episode - You are experiencing severe suicidal thoughts (with or without a recent attempt) - You are covered by health insurance - You have given your written informed consent **You may NOT be eligible if...** - You are currently dependent on opioids or other drugs of abuse - You have a serious heart condition (such as a prolonged QT interval on ECG) - You have severe liver or kidney disease - You are already taking certain medications that interact with buprenorphine (such as MAO inhibitors) - You are pregnant or breastfeeding - You have a diagnosis of a psychotic disorder (like schizophrenia) - You are under legal guardianship or otherwise unable to consent Talk to your doctor to see if this trial is right for you.