Partial Breast Versus no Irradiation for Women With Early Breast Cancer

This trial is studying whether women with early-stage, low-risk breast cancer who have had surgery can safely skip radiation therapy altogether, compared to receiving targeted partial breast radiation. **You may be eligible if...** - You are a woman aged 60 years or older - You have had a diagnosis of early-stage breast cancer (non-lobular type, Grade 1 or 2) - Your tumor was 20 mm or smaller - The cancer had not spread to the lymph nodes - Your cancer is hormone receptor positive (estrogen receptor positive) - The surgical margins were clear (no cancer cells at the edge of the removed tissue) - You are willing to take hormonal therapy (such as tamoxifen or an aromatase inhibitor) **You may NOT be eligible if...** - Your cancer is lobular type, high-grade, or larger than 20 mm - The cancer had spread to the lymph nodes - You are not a candidate for hormonal therapy - You have had previous breast cancer or prior radiation to the breast - You have certain genetic mutations (like BRCA1/BRCA2) that increase recurrence risk Talk to your doctor to see if this trial is right for you.