Genetics Of Autoimmunity In Type I Diabetes
Medical College of Wisconsin
4,000 participants
Aug 1, 2001
OBSERVATIONAL
Conditions
Summary
The purpose of this study is to gain more information about the step-by-step process that causes someone to develop type 1 diabetes. Scientists think that a person's own immune system, directed by genetic and environmental factors play a major role in its development. Participation involves a blood draw, a brief medical history questionnaire and measurements of height and weight. Some participants will be asked to return for annual follow-up visits for 10 years.
Eligibility
Inclusion Criteria5
- Families where at least one first-degree family member has type 1 diabetes
- The diabetic proband in the family was diagnosed before the age of 39
- Family members must be at least 2 years old to participate
- No family history of type 1 diabetes or other autoimmune conditions
- Age 2 or older
Exclusion Criteria3
- Families with no history of type 1 diabetes
- Families with a history of diabetes that is not type 1 (LADA, MODY, type 2 etc.)
- Personal or family history of autoimmune disease
Interventions
Blood will be collected via venipuncture and analyzed. Blood samples will be analyzed for HLA haplotype (a genetic sequence related to type 1 diabetes susceptibility), plasma-induced signature, diabetes autoantibodies, complete blood count with differential, and serum and plasma for storage. For family members with diabetes, blood will also be tested for A1c.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT03648918