RecruitingNCT03648918

Genetics Of Autoimmunity In Type I Diabetes

Sponsor

Medical College of Wisconsin

Enrollment

4,000 participants

Start Date

Aug 1, 2001

Study Type

OBSERVATIONAL

Conditions

Diabetes Mellitus Diabetes Mellitus, Type 1 Type1 Diabetes Mellitus Type1diabetes

Summary

The purpose of this study is to gain more information about the step-by-step process that causes someone to develop type 1 diabetes. Scientists think that a person's own immune system, directed by genetic and environmental factors play a major role in its development. Participation involves a blood draw, a brief medical history questionnaire and measurements of height and weight. Some participants will be asked to return for annual follow-up visits for 10 years.

Eligibility

Min Age: 2 Years

Plain Language Summary

Simplified for easier understanding

This trial is studying the genetics of Type 1 diabetes within families, aiming to identify gene variants that increase the risk of developing the disease or related immune system problems. **You may be eligible if...** - Your family has at least one first-degree relative (parent, sibling, or child) diagnosed with Type 1 diabetes - The family member with diabetes was diagnosed before age 39 - Family members are at least 2 years old **You may NOT be eligible if...** - Your family has no documented history of Type 1 diabetes - Family members diagnosed with diabetes were diagnosed at age 40 or older - Family members are younger than 2 years old Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERBlood Collection

Blood will be collected via venipuncture and analyzed. Blood samples will be analyzed for HLA haplotype (a genetic sequence related to type 1 diabetes susceptibility), plasma-induced signature, diabetes autoantibodies, complete blood count with differential, and serum and plasma for storage. For family members with diabetes, blood will also be tested for A1c.