Disease Modifying Therapies Withdrawal in Inactive Secondary Progressive Multiple Sclerosis Patients Older Than 50 Years (STOP-I-SEP)

This trial is studying whether it is safe for people over 50 with secondary progressive multiple sclerosis (a form of MS where disability gradually worsens) to stop their disease-modifying medications, particularly when MS has been stable and not relapsing for several years. **You may be eligible if...** - You are over 50 years old - You have had a diagnosis of secondary progressive MS for at least 3 years - Your disability has been gradually worsening (not due to relapses) with an increase of at least 1 point on the disability scale since the progressive phase started - You have not had a relapse in the past 3 years - You are currently on a disease-modifying treatment for MS **You may NOT be eligible if...** - You have had a relapse in the past 3 years - You have active inflammation visible on recent MRI brain scans - Your MS is still in the relapsing-remitting phase - You have major health problems that would affect the study - You are pregnant or planning to become pregnant Talk to your doctor to see if this trial is right for you.