RecruitingNCT05357781

Immunoglobulin Deficiency a Treatable Cause of Fatigue in Patients With Multiple Sclerosis (MS)?

Immunoglobulin Deficiency a Treatable Cause of Fatigue in Patients With Multiple Sclerosis (MS)? - A Prospective Observational Fatigue Trial


Sponsor

Insel Gruppe AG, University Hospital Bern

Enrollment

106 participants

Start Date

Jul 1, 2022

Study Type

OBSERVATIONAL

Conditions

Summary

The investigators hypothesize that hypogammaglobulinemia (defined as IgG serum concentration \<7.0g/L) is a treatable cause of fatigue in people with MS: The primary objective is to prove the link between hypogammaglobulinemia and fatigue in patients with multiple sclerosis. The secondary objective is to show that fatigue is mediated via frequent infections in people with MS and hypogammaglobulinemia.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether low antibody levels (immunoglobulin deficiency) in people with multiple sclerosis (MS) may be causing fatigue, and whether treating this deficiency might help. **You may be eligible if...** - You have been diagnosed with multiple sclerosis (MS) according to standard 2017 criteria - You are between 18 and 65 years old - Your MS has been stable for the past 12 months (no relapses, no new brain lesions, no worsening disability) - You have been on the same MS treatment for at least 12 months - You are still able to walk without major disability **You may NOT be eligible if...** - You have severe depression - Your MS has been active or changing recently - You have changed MS treatments in the past year - You have significant walking disability Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTLaboratory test

Frequency of fatigue (defined as Fatigue Scala for Motor and Cognitive Function (FSMC) total ≥ 43 points) in MS patients with IgG-deficiency


Locations(1)

University Hospital of Bern Inselspital

Bern, Canton of Bern, Switzerland

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NCT05357781


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