RecruitingNCT03657732

The Chinese Familial Alzheimer's Network

A Multi-center Longitudinal Cohort Study of Familial Alzheimer's Disease in China

Sponsor

Capital Medical University

Enrollment

40,000 participants

Start Date

Jan 10, 2005

Study Type

OBSERVATIONAL

Conditions

Alzheimer Disease Familial Alzheimer Disease (FAD)

Summary

This research will establish and continuously improve the FAD research network in conjunction with multi-center institutions nationwide. By collecting information on the family's demography, genetics, neuropsychology, neuroimaging, biomarkers and other information, we can understand the current FAD population in China, clarify the genetic characteristics, pathogenesis, disease characteristics and diagnosis and treatment status of AD in China; which will lay the foundation for ameliorating clinical diagnosis and treatment, establishing a Chinese FAD clinical database and an international cooperative research platform. 1. To set up a multi-center, nationwide FAD research network and database platform in China 2. To clarify the epidemiological characteristics of FAD in China. 3. To clarify the genetic characteristics of FAD in China. 4. To clarify the clinical characteristics and disease development laws of FAD. 5. To discover and verify the early diagnosis biomarkers of AD. 6. To establish a genetic counseling model.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is building a network of Chinese families affected by Alzheimer's disease that runs in families (familial Alzheimer's), with the goal of finding genetic causes and understanding how the disease develops over time. **You may be eligible if...** - You are part of a family where at least two first-degree relatives have been diagnosed with Alzheimer's disease (confirmed clinically or by testing) - At least 3 family members across 2 generations are affected - You are willing to give written consent (or a legal guardian can consent on your behalf) **You may NOT be eligible if...** - Your family does not have a pattern of familial Alzheimer's disease (at least 2 first-degree relatives affected) - You are not willing or able to provide consent - You have been previously diagnosed with a non-Alzheimer's cause of dementia in your family Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(65)

The First Affiliated Hospital of Anhui Medical University

Hefei, Anhui, China

Beijing Geriatric Hospital

Changping, Beijing Municipality, China

Beijing Chao Yang Hospital

Chaoyang, Beijing Municipality, China

China-Japan Friendship Hospital

Chaoyang, Beijing Municipality, China

Dongfang Hospital Affiliated to Beijing University of Chinese Medicine

Fengtai, Beijing Municipality, China

Chinese PLA General Hospital

Haidian, Beijing Municipality, China

Fu Xing Hospital, Capital Medical University

Haidian, Beijing Municipality, China

Peking University Third Hospital

Haidian, Beijing Municipality, China

Peking Union Medical College Hospital

Xicheng, Beijing Municipality, China

Peking University First Hospital

Xicheng, Beijing Municipality, China

Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

Yuzhong, Chongqing Municipality, China

The Second Affiliated Hospital of Chongqing Medical University

Yuzhong, Chongqing Municipality, China

Fujian Medical University Union Hospital

Fujian, Guangdong, China

Guangzhou Psychiatric Hospital

Guangzhou, Guangdong, China

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Zhongshan, Guangdong, China

First Affiliated Hospital of Guangxi Medical University

Nanning, Guangxi, China

The Affiliated Hospital Of Guizhou Medical University

Guiyang, Guizhou, China

Handan Central Hospital

Handan, Hebei, China

First Hospital of Shijiazhuang City

Shijiazhuang, Hebei, China

Tangshan Worker's Hospital

Tangshan, Hebei, China

Hebei General Hospital

Zhijiazhuang, Hebei, China

First Affiliated Hospital of Harbin Medical University

Haerbin, Heilongjiang, China

Kaifeng Central Hospital

Kaifeng, Henan, China

Henan Provincial People's Hospital

Zhengzhou, Henan, China

People's Hospital of Zhengzhou

Zhengzhou, Henan, China

People's Hospital Affiliated Hubei Medical University

Wuhan, Hubei, China

Tongji Hospital

Wuhan, Hubei, China

The Third Xiangya Hospital of Central South University

Wuhan, Hunan, China

Wuhan University Zhongnan Hospital

Wuhan, Hunan, China

Xiangya Hospital of Central South University

Wuhan, Hunan, China

Nantong University Affiliated Hospital

Nantong, Jiangsu, China

Subei People's Hospital of Jiangsu

Subei, Jiangsu, China

Mineral General Hospital, Xuzhou

Xuzhou, Jiangsu, China

Jiangxi Provincial People's Hospital

Nanchang, Jiangxi, China

China-Japan friendship Hospital of Jilin university

Changchun, Jilin, China

The First Hospital of Jilin University

Changchun, Jilin, China

Changda Hospital, Anshan

Anshan, Liaoning, China

Affiliated Zhongshan hospital of Dalian university

Dalian, Liaoning, China

The First Affiliated Hospital of Dalian Medical University

Dalian, Liaoning, China

First Hospital of China Medical University

Shenyang, Liaoning, China

Baotou Central Hospital

Baotou, Nei Monggol, China

General Hospital of Ningxia Medical University

Yinchuan, Ningxia, China

The People's Hospital of Ningxia

Yinchuan, Ningxia, China

Qilu Hospital of Shandong University

Jinan, Shandong, China

Shandong Provincial Hospital

Jining, Shandong, China

Qilu Hospital of Shandong University (Qingdao)

Qingdao, Shandong, China

QingDao Municipal Hospital

Qingdao, Shandong, China

The Affiliated Hospital of Qingdao University

Qingdao, Shandong, China

The 88th Hospital of PLA

Tai’an, Shandong, China

Shanghai Changzheng Hospital

Huangpu, Shanghai Municipality, China

Ruijin Hospital

Luwan, Shanghai Municipality, China

RenJi Hospital

Putong, Shanghai Municipality, China

The First Affiliated Hospital of Shanxi Medical University

Taiyuan, Shanxi, China

First Affiliated Hospital Xi'an Jiaotong University

Xi’an, Shanxi, China

Tang-Du Hospital

Xi’an, Shanxi, China

Afﬁliated Hospital of North Sichuan Medical College

Nanchong, Sichuan, China

Zigong First People's Hospital

Zigong, Sichuan, China

Tianjin Huanhu Hospital

Xianshuigu, Tianjin Municipality, China

Tianjin Medical University General Hospital

Xiaobailou, Tianjin Municipality, China

Traditional Chinese Medicine Hospital of Xinjiang Autonomous Region

Ürümqi, Xinjiang, China

First Affiliated Hospital of Zhejiang University

Hangzhou, Zhejiang, China

Shao Yifu Hospital of Zhejiang Medical University

Hangzhou, Zhejiang, China

Zhejiang Provincial People's Hospital

Hangzhou, Zhejiang, China

Ningbo City Medical Treatment Center Lihuili Hospital

Ningbo, Zhejiang, China

First Affiliated Hospital of Wenzhou Medical Univeristy

Wenzhou, Zhejiang, China

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NCT03657732

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Conditions

Summary

Eligibility

Plain Language Summary

Locations(65)

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