Leveraging Biomarkers for Personalized Treatment of Alcohol Use Disorder Comorbid With PTSD

This trial is studying personalized treatment for people who have both alcohol use disorder and PTSD (post-traumatic stress disorder) at the same time, using brain scans and biological markers to match each person to the treatment most likely to help them. **You may be eligible if...** - You are between 18 and 70 years old - You have been diagnosed with moderate or severe alcohol use disorder - You want to cut down or stop drinking - You have had at least 4 heavy drinking days in the past 30 days (4+ drinks/day for women, 5+ drinks/day for men) - You have been diagnosed with current PTSD or significant PTSD symptoms **You may NOT be eligible if...** - You are currently using illicit drugs or have another serious substance use disorder - You have a serious psychiatric condition (such as bipolar disorder or psychosis) - You have a serious medical condition that would make the study risky - You are currently on medications that interact with the study drugs - You are pregnant or breastfeeding - You have active suicidal intent requiring immediate care Talk to your doctor to see if this trial is right for you.