RecruitingNot ApplicableNCT03674307

Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates

Canadian-Australasian Randomised Trial of Screening Kidney Transplant Candidates for Coronary Artery Disease

Sponsor

University of British Columbia

Enrollment

3,306 participants

Start Date

Dec 1, 2018

Study Type

INTERVENTIONAL

Conditions

Cardiovascular Diseases End Stage Renal Disease Kidney Transplantation Dialysis Related Complication

Summary

The Canadian Australasian Randomized Trial of Screening Kidney Transplant Candidates for Coronary Artery Disease (CARSK) will test the hypothesis that eliminating the regular use of non-invasive screening tests for CAD AFTER waitlist activation is not inferior to regular (i.e., annual) screening for CAD during wait-listing for the prevention of Major Adverse Cardiac Events. Secondary analyses will assess the impact of screening on the rate of transplantation, and the relative cost-effectiveness of screening.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial compares two methods of screening for hidden coronary artery disease (CAD) in people waiting for a kidney transplant, to find the safest and most effective approach. You may be eligible if... - You are an adult (18 or older) with kidney failure requiring dialysis - You are currently being assessed for or are on the kidney transplant waiting list - You need additional heart screening before transplant per current guidelines - Your expected transplant is more than 12 months away You may NOT be eligible if... - You have signs of uncontrolled heart disease (unstable coronary syndrome, severe arrhythmia, decompensated heart failure, or severe valve disease) - You are currently on hold for transplant due to a medical issue - You have had another solid organ transplant or are being considered for a combined organ transplant - You have a planned living donor transplant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERNo screening

No further screening for asymptomatic coronary artery disease after wait-list entry

OTHERRegular Screening

Annual or second-yearly screening for asymptomatic coronary artery disease after wait-list entry

Locations(22)

University of Arizona

Tucson, Arizona, United States

The George Washington University

Washington D.C., District of Columbia, United States

University of Alberta

Edmonton, Alberta, Canada

University of British Columbia

Vancouver, British Columbia, Canada

Dalhousie University

Halifax, Nova Scotia, Canada

St. Joseph's Healthcare

Hamilton, Ontario, Canada

Kingston Health Science Centre

Kingston, Ontario, Canada

London Health Science Centre

London, Ontario, Canada

The Ottawa Hospital Research Institute

Ottawa, Ontario, Canada

University Health Network

Toronto, Ontario, Canada

St Michael's Hospital

Toronto, Ontario, Canada

CHU de Quebec-Universite Laval's L'Hotel-Dieu de Quebec

Laval, Quebec, Canada

University of Montreal, Maisonneuve-Rosemont Hospital

Montreal, Quebec, Canada

McGill University Health Centre

Montreal, Quebec, Canada

Universite de Montreal, Hopital Maisonneuve-Rosemont

Montreal, Quebec, Canada

St. Paul's Hospital, University of Saskatchewan

Saskatoon, Saskatchewan, Canada

Charité Universitätsmedizin

Berlin, Germany

Sussex Brighton R&D

Brighton, United Kingdom

King's College Hospital NHS Foundation Trust

Brixton, United Kingdom

Epsom and St Helier University Hospitals NHS Trust

Carshalton, United Kingdom

Barts Health NHS Trust

London, United Kingdom

St George's University Hospital NHS Trust Foundation

London, United Kingdom

View Full Details on ClinicalTrials.gov

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NCT03674307

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