RecruitingPhase 2NCT03681275

Janus Kinase Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction

A Clinical Trial of JAK Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction

Sponsor

Stanford University

Enrollment

70 participants

Start Date

Sep 3, 2019

Study Type

INTERVENTIONAL

Conditions

Diaphragm Injury

Summary

We intend, with this study, to prove that blocking the molecular mechanisms whose blockade prevents VIDD in animals, will indeed prevent the development of VIDD in humans as well. We believe that this evidence will serve as the required basis for proceeding with large, ICU-based clinical trial(s) of a drug to prevent VIDD.

Eligibility

Min Age: 18 Years

Inclusion Criteria1

Patients undergoing esophagectomy

Exclusion Criteria7

Patients with more than mild pulmonary dysfunction
Patients with any neuromuscular disease that might compromise diaphragm function
Patients with abnormal liver or kidney function
Patients taking any immunosuppressant medication (including prednisone) or antifungal medications
History of tuberculosis
Weight loss of >5% of body weight over previous 6 months
Pregnancy

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