Exploration of Mechanisms for Weaning Failure
Changes in Respiratory Mechanics in Patients With Failed Ventilator Withdrawal
The First Affiliated Hospital of Guangzhou Medical University
30 participants
Jul 9, 2024
OBSERVATIONAL
Conditions
Summary
This study is a prospective physiologic study. The primary study population will be adult invasive tracheal intubated patients with COPD, and investigators will collect relevant demographic data, vital signs, and baseline physiologic parameters of the patients prior to the spontaneous breathing test(SBT). The participants will be divided into a successful withdrawal group and a failed withdrawal group according to the SBT outcome, and the changes in the above parameters during SBT will be compared between the two groups .
Eligibility
Inclusion Criteria1
- Invasive mechanical ventilation for at least 48 hours
Exclusion Criteria1
- neuromuscular disease;Postoperative patients or patients with traumatic brain injury
Interventions
Physiologic recording instrumentation measure maximal transdiaphragmatic pressure,twitch diaphragmatic pressure and maximal diaphragmatic electromyography
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06424314