RecruitingNCT06424314

Exploration of Mechanisms for Weaning Failure

Changes in Respiratory Mechanics in Patients With Failed Ventilator Withdrawal

Sponsor

The First Affiliated Hospital of Guangzhou Medical University

Enrollment

30 participants

Start Date

Jul 9, 2024

Study Type

OBSERVATIONAL

Conditions

Weaning Failure Central Respiratory Depression Diaphragm Injury Phrenic Nerve Disorder

Summary

This study is a prospective physiologic study. The primary study population will be adult invasive tracheal intubated patients with COPD, and investigators will collect relevant demographic data, vital signs, and baseline physiologic parameters of the patients prior to the spontaneous breathing test（SBT). The participants will be divided into a successful withdrawal group and a failed withdrawal group according to the SBT outcome, and the changes in the above parameters during SBT will be compared between the two groups .

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is exploring what physiological factors make it difficult to wean patients off mechanical ventilators (breathing machines) after being on one for at least 48 hours. The goal is to better understand why some patients struggle to breathe independently again. **You may be eligible if...** - You have been on a mechanical ventilator for at least 48 hours - You are in the ICU and being assessed for the possibility of coming off the ventilator **You may NOT be eligible if...** - You have a neuromuscular disease (such as ALS or muscular dystrophy) - You are recovering from surgery or traumatic brain injury Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTMonitoring of respiratory mechanics parameters

Physiologic recording instrumentation measure maximal transdiaphragmatic pressure，twitch diaphragmatic pressure and maximal diaphragmatic electromyography

Locations(1)

The First Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China

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NCT06424314

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