RecruitingNCT06424314

Exploration of Mechanisms for Weaning Failure

Changes in Respiratory Mechanics in Patients With Failed Ventilator Withdrawal


Sponsor

The First Affiliated Hospital of Guangzhou Medical University

Enrollment

30 participants

Start Date

Jul 9, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

This study is a prospective physiologic study. The primary study population will be adult invasive tracheal intubated patients with COPD, and investigators will collect relevant demographic data, vital signs, and baseline physiologic parameters of the patients prior to the spontaneous breathing test(SBT). The participants will be divided into a successful withdrawal group and a failed withdrawal group according to the SBT outcome, and the changes in the above parameters during SBT will be compared between the two groups .


Eligibility

Min Age: 18 Years

Inclusion Criteria1

  • Invasive mechanical ventilation for at least 48 hours

Exclusion Criteria1

  • neuromuscular disease;Postoperative patients or patients with traumatic brain injury

Interventions

DIAGNOSTIC_TESTMonitoring of respiratory mechanics parameters

Physiologic recording instrumentation measure maximal transdiaphragmatic pressure,twitch diaphragmatic pressure and maximal diaphragmatic electromyography


Locations(1)

The First Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China

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NCT06424314