ECoG BMI for Motor and Speech Control

This study is developing a brain-computer interface — a device implanted in the brain — that reads electrical signals from the brain and translates them into movement or speech for people with serious paralysis or loss of limb function, with the goal of restoring independence. **You may be eligible if...** - You are over 21 years old - You have severely limited use of both arms due to stroke, ALS (Lou Gehrig's disease), multiple sclerosis, spinal cord injury, brainstem stroke, muscular dystrophy, or severe nerve disease - Your disability is severe (Modified Rankin Scale score of 4 or more) - At least 1 year has passed since your stroke or spinal cord injury - You live within a 2-hour drive of UCSF **You may NOT be eligible if...** - You are pregnant or breastfeeding - You cannot understand or read English - You have dementia - You have active severe depression, schizophrenia, bipolar disorder, OCD, or certain personality disorders - You have a history of suicide attempt - You have a history of substance abuse - You have cancer, uncontrolled high blood pressure, or major organ failure - You have had prior brain surgery or a history of seizures - You have an implanted electronic device (pacemaker, neurostimulator, etc.) Talk to your doctor to see if this trial is right for you.