The Bern Heart and Brain Interaction Study - Interaction Between Brain and Heart in Acute Ischemic Stroke
Insel Gruppe AG, University Hospital Bern
220 participants
Dec 1, 2018
OBSERVATIONAL
Conditions
Summary
Acute ischemic stroke is caused by blockage of blood vessels in the brain. Blood vessels can be obstructed by several different mechanisms and identification of this cause is essential to minimize the risk of recurrence.
Eligibility
Inclusion Criteria4
- Informed consent as documented by signature.
- Age: ≥ 18 and < 86 years.
- Acute ischemic stroke with symptom onset within 12 hours before admission to hospital.
- Diagnosis of acute ischemic stroke with MRI with diffusion restriction as seen on diffusion weighted imaging.
Exclusion Criteria3
- Pregnancy. A negative pregnancy test upon admission is required for all women with child-bearing potential.
- Standard contraindication for performing MRI.
- Severe renal failure (GFR <40).
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Interventions
A short CMR without additional contrast administration will be performed immediately after the routine brain MRI (at admission or after 24h).
An adenosine-perfusion CMR using contrast medium (gadolinium) will be performed in all patients (except group 1) between 48h and 6 days after admission.
The following study-specific parameters will be tested: neuropeptide Y 1-36, neuropeptide Y 3-36, total plasma metanephrines, metabolomics analysis Time points for blood draw: at admission (routine), 3h (routine), 24h (routine), 48h, 72h and 3 months.
The following study-specific parameters will be tested: catecholamines. Time points for collection: at 24h, 72h, and 3 months
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT03720522