Circulating Non-coding RNA in Acute Ischemic Stroke (AISRNA)
Clinical Significance of Circulating Non-coding RNA in Acute Ischemic Stroke (AISRNA)
Nanjing First Hospital, Nanjing Medical University
500 participants
Nov 24, 2019
OBSERVATIONAL
Conditions
Summary
AISRNA is to analyze the expression pattern of circular RNA (circRNA), micro-RNA (miRNA) and long non-coding RNA (lncRNA) by next-generation sequencing in patients with acute ischemic stroke and healthy control. The candidate circRNA/miRNA/lncRNA will be verified as biomarkers for the detection and prognosis of acute ischemic stroke.
Eligibility
Inclusion Criteria5
- Aged 18 years or older
- Confirmed acute ischemic stroke by a diffusion-weighted imaging-position lesion on magnetic resonance imaging (MRI) and a new lesion on a brain computed tomography (CT) scan
- Within 72 hours of symptom onset
- Good performance status
- Signed an approved informed consents
Exclusion Criteria1
- a history of hemorrhagic infarction, chronic kidney/liver diseases, peripheral arterial occlusive disease, active malignant disease, and inflammatory or infectious diseases
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Interventions
Next generation sequencing of circular RNA (circRNA), micro-RNA (miRNA) and long non-coding RNA (lncRNA)
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT04175691