Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.

This trial is using a specialized brain scan called a PET scan (with a tracer called DPA-714) to look for inflammation in the brain and nervous system in people with multiple sclerosis (MS), fibromyalgia, or chronic fatigue syndrome, to better understand these conditions. **You may be eligible if...** - You are aged 18–65 years - You are a healthy volunteer, OR have a confirmed diagnosis of multiple sclerosis (MS), fibromyalgia, or chronic fatigue syndrome (CFS/ME) - You are able to undergo MRI and PET brain scans **You may NOT be eligible if...** - You have a contraindication to MRI (e.g., certain metal implants) - You are pregnant or breastfeeding - You have a chronic infectious disease (such as HIV or Hepatitis C) - You had a recent viral or bacterial illness requiring antibiotics - Your medical condition is too severe to participate in the imaging procedures Talk to your doctor to see if this trial is right for you.