RecruitingPhase 1NCT03764748
Washed Microbiota Transplantation for Tourette's Syndrome
Efficacy and Safety of Washed Microbiota Transplantation for Tourette's Syndrome
Sponsor
The Second Hospital of Nanjing Medical University
Enrollment
30 participants
Start Date
Apr 17, 2024
Study Type
INTERVENTIONAL
Conditions
Summary
This study aimed to evaluate the efficacy of washed microbiota transplantation in the treatment of Tourette's syndrome (TS).
Eligibility
Min Age: 6 YearsMax Age: 17 Years
Inclusion Criteria4
- Patients were aged 6 to 17 years (inclusive);
- Met the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria for TS;
- Had a Yale Global Tic Severity Scale-Total Tic Score (YGTSS-TTS) of at least 20 at screening and baseline.
- Underwent WMT.
Exclusion Criteria7
- Complicated with certain brain disease, including tumor,injury,cerebrovascular disease;
- Complicated with other severe disease, including cancers, organ failure, heart diseases;
- Stereotypy associated with autism spectrum disorder;
- With a confirmed diagnosis of psychiatric diseases, such as bipolar disorders; schizophrenia and major depressive disorders;
- Clinically significant obsessive-compulsive disorder at baseline considered to be the primary cause of impairment at baseline;
- Medications use affecting gut microbiota such as antibiotics and probiotics three months before WMT.
- Other neurologic disorders other than TS that could influence the evaluation of tics.
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
DRUGWashed Microbiota Transplantation
The prepared microbiota suspension was infused into the participates' lower gut.
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT03764748
Related Trials
CBIT+TMS R33 Phase
NCT066787371 location
A Multicenter Pediatric Deep Brain Stimulation Registry
NCT065856181 location
Sensory Symptoms in Tourette Syndrome
NCT038514842 locations
Observational Database on Deep Brain Stimulation in Tourette Syndrome
NCT044490681 location
Epidemiology of Assertiveness and Emotion Management Disorders in People With Tourette's Syndrome
NCT061365721 location