Neuromodulation and Cognitive Training in Opioid Use Disorder

This University of Minnesota study is testing whether a combination of transcranial direct current stimulation (tDCS) — a non-invasive brain stimulation technique — and cognitive training can help people with opioid use disorder (OUD) improve their decision-making and self-control during early abstinence. The study enrolls people in a 28-day residential recovery program who are in their first 1–2 weeks of abstinence from opioids. You may be eligible if: - You are between 18 and 60 years old - You meet DSM-5 criteria for opioid use disorder as your primary substance use disorder - You have been abstinent from opioids for 1–2 weeks - You are enrolled in the Lodging Plus residential program at the University of Minnesota Medical Center - You plan to remain in the program for the full 4 weeks You may NOT be eligible if: - You have a neurological condition (stroke, brain tumor, significant head injury with >30 min loss of consciousness, HIV-related neurological issues) - You have contraindications to tDCS or MRI (history of seizures, metal implants, pacemakers, pregnancy, braces, non-removable piercings) - You have a current (not lifetime) DSM-5 psychiatric disorder (except depression history) - Your primary substance use disorder is something other than opioids (caffeine and nicotine are acceptable) - You are outside the age range of 18–60 Talk to your addiction medicine provider about whether this brain stimulation and cognitive training study is appropriate during your current recovery program.