Opioid Dependence Clinical Trials

12 recruitingLast updated: June 18, 2026

There are 12 actively recruiting opioid dependence clinical trials across 4 countries. Studies span Not Applicable, Phase 4, Phase 1, Phase 2. Top locations include Indianapolis, Indiana, United States, Faversham, Kent, United Kingdom, Herston, Queensland, Australia. Updated daily from ClinicalTrials.gov.


Opioid Dependence Trials at a Glance

12 actively recruiting trials for opioid dependence are listed on ClinicalTrialsFinder across 6 cities in 4 countries. The largest study group is Not Applicable with 5 trials, with the heaviest enrollment activity in Indianapolis, Faversham, and Herston. Lead sponsors running opioid dependence studies include Inventage Lab., Inc., Jenna-Leigh Wilson, and Indiana University.

Browse opioid dependence trials by phase

Treatments under study

About Opioid Dependence Clinical Trials

Looking for clinical trials for Opioid Dependence? There are currently 13 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Opioid Dependence trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Opioid Dependence clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 112 of 12 trials

Recruiting
Not Applicable

Neuromodulation and Cognitive Training in Opioid Use Disorder

Opioid-use DisorderOpioid DependenceOpioid Abuse
University of Minnesota30 enrolled1 locationNCT03773523
Recruiting
Phase 4

Better Options for Chronic Cancer Pain

Chronic PainCancer SurvivorOpioid Dependence
VA Office of Research and Development294 enrolled2 locationsNCT06574009
Recruiting
Phase 1

STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis

Pancreatic SurgeryChronic PainChronic Pancreatitis+7 more
Indiana University24 enrolled5 locationsNCT05603702
Recruiting
Not Applicable

Reducing Opioid Use for Chronic Pain Patients Following Surgery

Opioid UsePostoperative PainChronic Pain+1 more
University Health Network, Toronto210 enrolled1 locationNCT03675386
Recruiting
Phase 4

Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery

Opioid analgesiaPain, PostoperativeOpioid-use Disorder+2 more
Jenna-Leigh Wilson100 enrolled1 locationNCT06949826
Recruiting
Not Applicable

The MOUD Plus Pilot: Counseling and Peer Support to Support Retention for Medically Complex Patients With Opioid Use Disorder Seen In Primary Care

Opioid DependencePrimary Care Patients With Chronic ConditionsSubstance Abuse Disorders+1 more
Oregon Health and Science University70 enrolled1 locationNCT06837662
Recruiting
Phase 2

Standardized Natural Psilocybin-assisted Psychotherapy for Tapering of Opioid Medication

Chronic PainOpioid Dependence
University of British Columbia10 enrolled1 locationNCT05585229
Recruiting

fMRI and Opioid Abstinence

Opioid UseOpioid DependenceOpioid Abuse+2 more
Yale University240 enrolled1 locationNCT06651333
Recruiting
Phase 4

Young Houston Emergency Opioid Engagement System

Opioid UseSubstance Use DisordersOpioid-use Disorder+2 more
The University of Texas Health Science Center, Houston250 enrolled1 locationNCT04811014
Recruiting
Phase 1

A Clinical Trial to Assess Pharmacokinetic Profiles, Safety and Tolerability of IVL3004 and IVL4002 in Healthy Male Subjects.

Multiple SclerosisOpioid DependenceAlcohol Dependence
Inventage Lab., Inc.40 enrolled1 locationNCT05620940
Recruiting
Not Applicable

Text-Messaging Telehealth and Contingency Management for Opioid Use Disorder Treatment Engagement

Opioid-use DisorderOpioid Dependence With Current Use (Disorder)
University of Pennsylvania1,808 enrolled1 locationNCT05897788
Recruiting
Not Applicable

DE-eSCALation of Opioids Post-surgical dischargE

Opioid Dependence
University of Kent100 enrolled1 locationNCT06396663