Post-Op Pain Control for Prophylactic Intramedullary Nailing.

This trial is comparing different methods of pain control after a surgery called prophylactic intramedullary nailing — a procedure where a metal rod is inserted inside a weakened thigh bone (femur) to prevent it from breaking, often done in cancer patients whose bones are weakened by the disease. **You may be eligible if...** - You are 18 years or older - You have a bone lesion (a weakened or abnormal area) in your thigh bone (femur shaft or neck) - You are scheduled to have prophylactic intramedullary nailing of one femur (the rod-insertion surgery) **You may NOT be eligible if...** - You already have a broken bone at the site of surgery - You have severe kidney disease (eGFR below 30) - You have a history of peptic ulcers with bleeding or requiring hospitalization - You have an allergy to NSAIDs (like ibuprofen) or aspirin - Your chemotherapy regimen prevents NSAID use - You have liver disease, heart failure, or cardiovascular disease that prevents use of certain pain medications - You are pregnant, or have a bleeding disorder or are on blood thinners Talk to your doctor to see if this trial is right for you.