RecruitingNCT03835273

Oesophagectomy and Chest Wall and Respiratory Function

Changes in Respiratory Function and Chest Wall Movement Following Oesophagectomy

Sponsor

Imperial College London

Enrollment

100 participants

Start Date

May 29, 2019

Study Type

OBSERVATIONAL

Conditions

Esophageal Cancer Esophagectomy Respiratory Function Loss

Summary

Open surgery for esophageal cancer commonly involves large incisions in the chest, associated with a high rate of pulmonary complications (30-50%). Minimally invasive approach through keyhole surgery has been shown to reduce pulmonary infections by 20%. Enhanced recovery programmes are evidence-based protocols, developed to achieve early recovery after surgery with early mobilisation and chest physiotherapy and have been shown to reduce pulmonary complication rates as well. The investigators intend to objectively measure chest wall movement using 3D motion capture system as well as a wearable measurement system to monitor chest wall movement.

Eligibility

Min Age: 18 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study is measuring lung and chest wall function in people who had surgery to remove part of their esophagus (food pipe) for esophageal cancer more than a year ago, to better understand the long-term effects of this major surgery on breathing. **You may be eligible if...** - You had an open surgery to remove part of your esophagus (esophagectomy) for esophageal cancer more than one year ago, OR - You are a healthy volunteer with no lung problems and no history of upper digestive surgery (to serve as a comparison group) - You are between 18 and 90 years old - You are able to understand information and give your consent **You may NOT be eligible if...** - You are unable to give informed consent - There is evidence your cancer has returned, OR you are still dealing with surgical complications from the operation - You are pregnant - You are unable to do simple breathing tests (spirometry or respiratory muscle strength testing) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHER3D motion capture system

Small reflective markers and inertia measurement units will be placed on the chest of the patients using hypoallergenic adhesive and a motion capture system will pick up a 3D image via these markers non-invasively.

OTHERIncentive spirometry

Incentive spirometry is a non-invasive device for assessment of pulmonary function.

OTHERQuestionnaires

Three validated, European Organisation for Research and Treatment of Cancer Quality-of-life Questionnaire Core 30 (EORTC QLQ-C30) and Oesophago-Gastric Module 25 (EORTC QLQ-OG25) and LASORS questionnaire.