RecruitingPhase 1Phase 2NCT03836950

rTMS to Improve Cognition in Parkinson's

rTMS as a Cognitive Rehabilitation Approach in Veterans With Parkinson's Disease


Sponsor

VA Office of Research and Development

Enrollment

56 participants

Start Date

Apr 1, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to examine safety, feasibility, and the behavioral and brain effects of a non-invasive treatment, repetitive transcranial magnetic stimulation (rTMS), for Veterans with Parkinson's disease or atypical parkinsonism and mild impairments in their thinking. The hypothesis is that rTMS can improve thinking for people with Parkinson's disease or atypical parkinsonism who are experiencing mild problems with their thinking ability.


Eligibility

Min Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether repetitive transcranial magnetic stimulation (rTMS) — a non-invasive brain stimulation technique that uses magnetic pulses on the scalp — can improve thinking and memory problems in veterans who have Parkinson's disease or a related condition. **You may be eligible if...** - You are a veteran who receives care at Hines VA Hospital or Jesse Brown VA Medical Center - You have been diagnosed with Parkinson's disease or a related condition by a neurologist - You have been diagnosed with mild thinking or memory problems (mild cognitive impairment) - You are on a stable medication regimen (no changes planned) - You speak and read English - You are 50 years old or older **You may NOT be eligible if...** - You have been diagnosed with dementia - You have had deep brain stimulation surgery - You have a pacemaker, defibrillator, cochlear implant, nerve stimulator, or metal in your head - You have severe depression or severe tremors that interfere with testing - You have a history of seizures or epilepsy - You have claustrophobia or cannot undergo MRI scanning - You have significant heart failure Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEMagVenture MagProX100 stimulator (MagVenture, Falun, Denmark)

The coil will be held tangentially to the skull at approximately 45º from the midline. One rTMS session will consist of 40 trains of 5sec each at 110% of resting motor threshold and 15Hz will be provided at the left DLPFC.

DEVICEMagVenture MagProX100 stimulator (MagVenture, Falun, Denmark)

The coil will be held tangentially to the skull at approximately 45º from the midline. The sham coil will not release any stimulation, but it will look, feel and sound like the real rTMS


Locations(2)

Jesse Brown VA Medical Center, Chicago, IL

Chicago, Illinois, United States

Edward Hines Jr. VA Hospital, Hines, IL

Hines, Illinois, United States

View Full Details on ClinicalTrials.gov

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NCT03836950


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