RecruitingPhase 3NCT03848312

Preventing Alzheimer's With Cognitive Training

Cognitive Training to Reduce Incidence of Cognitive Impairment in Older Adults


Sponsor

University of South Florida

Enrollment

7,600 participants

Start Date

Feb 19, 2019

Study Type

INTERVENTIONAL

Conditions

Summary

Dementia is the most expensive medical condition in the US and increases in prevalence with age. More than 5 million Americans have Alzheimer's disease, the most common form of dementia. Mild cognitive impairment is a transitional stage between normal cognitive aging and Alzheimer's disease or another type of dementia, and is indicative of higher risk for dementia. In addition to the obvious health and quality-of-life ramifications of dementia, there are high direct (e.g., subsidizing residential care needs) and indirect (e.g., lost productivity of family caregivers) economic costs. Implementing interventions to prevent MCI and dementia among older adults is of critical importance to health and maintained quality-of-life for millions of Americans. Recent data analyses from the Advanced Cognitive Training in Vital Elderly study (ACTIVE) indicate that a specific cognitive intervention, speed of processing training (SPT), significantly delays the incidence of cognitive impairment across 10 years. The primary contribution of the proposed research will be the determination of whether this cognitive training technique successfully delays the onset of clinically defined MCI or dementia across three years.


Eligibility

Min Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a structured computer-based brain training program can help older adults protect and improve their memory and thinking skills as they age. You may be eligible if: - You are 65 years or older - You can speak and understand English or Spanish - You have adequate vision, hearing, and ability to use a computer touchscreen or mouse - You do not currently have mild cognitive impairment or dementia (a memory screening score will confirm this) - You have good mental health that would not interfere with participating - You are willing to complete all study activities throughout the entire study period You may NOT be eligible if: - You are currently enrolled in another study that tests thinking or memory - You have previously participated in a cognitive training study - You have been diagnosed with mild cognitive impairment, dementia, stroke, brain injury, a brain tumor, or a neurological condition like Parkinson's disease or multiple sclerosis - You have an unstable health condition expected to cause rapid decline (like heart failure, severe COPD needing oxygen, or active chemotherapy) - You currently take memory medications (such as donepezil, memantine, or others) - You have used a computerized brain training program (like Lumosity or BrainHQ) for 10 or more hours in the last 5 years - You have significant depression symptoms Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALCognitive Training

Participants will be completing a total of 45 computerized sessions.

BEHAVIORALComputerized Cognitive Stimulation

Participants will be completing a total of 45 computerized cognitive stimulation sessions.


Locations(7)

University of Florida

Gainesville, Florida, United States

University of Florida

Jacksonville, Florida, United States

University of North Florida

Jacksonville, Florida, United States

The Roskamp Institute

Sarasota, Florida, United States

University of South Florida

Tampa, Florida, United States

Duke Health

Durham, North Carolina, United States

Clemson University Institute for Engaged Aging

Seneca, South Carolina, United States

View Full Details on ClinicalTrials.gov

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NCT03848312


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