High Frame Rate Ultrasound in Heart Disease Assessment
High Frame Rate Contrast Enhanced-ultrasound for the Assessment of Ischaemic Heart Disease
London North West Healthcare NHS Trust
25 participants
Feb 1, 2022
OBSERVATIONAL
Conditions
Summary
The study will compare standard ultrasound images to high frame rate ultrasound images in patients with heart disease or with a low risk of heart disease to see if a higher frame rate of ultrasound adds to the information obtained from standard ultrasound.
Eligibility
Inclusion Criteria6
- Ability to give informed consent
- age ≥18years and
- confirmed inducible wall motion / perfusion abnormality on previous stress echocardiogram
- known coronary artery disease - defined by presence of flow-limiting coronary stenosis(>70% diameter stenosis) on coronary angiography.
- OR
- patient who has been assessed as at low risk of having coronary heart disease
Exclusion Criteria11
- Inability to undertake pharmacological stress, ie previously known intolerance to dipyridamole;
- Moderate or Severe aortic or mitral regurgitation or severe mitral stenosis;
- Significant pulmonary disease like severe COPD or pulmonary fibrosis;
- Atrial fibrillation;
- Inability to provide informed consent;
- Pregnancy and lactation;
- Known allergy to Sonovue
- Patients with second and third degree heart block, unless they have a pacemaker fitted
- Systolic BP < 90
- Known Myasthenia Gravis
- Bronchial asthma
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Interventions
Patients will undergo standard echocardiography, with and without contrast
Following standard echocardiography, the test is repeated using high frame rate ultrasound
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT03850015