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RecruitingNCT03853447

Fibro-inflammatory Progression From Acute to Chronic Pancreatitis

Characterization of Fibro-inflammation During Progression From Acute to Chronic Pancreatitis

Sponsor

Copenhagen University Hospital, Hvidovre

Enrollment

150 participants

Start Date

Feb 14, 2019

Study Type

OBSERVATIONAL

Conditions

FibrosisPancreatitisChronic PancreatitisInflammationAcute PancreatitisRecurrent Pancreatitis

Summary

Observational prospective study evaluating the developement of chronic pancreatitis based on imaging modalities as well as biochemical markers of inflammation, fibrosis and oxidative stress.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Inclusion Criteria3

  • Patients with CP (N=50) of any aetiology except gallstone induced CP: CP will be diagnosed based on MANNHEIM criteria .
  • Cohort 2: Patients with their first attack of AP of any aetiology except gallstone induced AP (N=50). The revised Atlanta criteria for acute pancreatitis will be used as diagnostic criteria.
  • Cohort 3: Patients with RAP (N=50) except gallstone induced RAP. RAP is defined as two or more cases of AP as diagnosed by the revised Atlanta Criteria.

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Interventions

DIAGNOSTIC_TESTDiagnostic imaging

MRI assessments including magnetic resonance cholangiopancreatography (MRCP) and diffusion weighted imaging (DWI) combined with gold standard EUS

Locations(3)

Gastrounit, Copenhagen University Hospital Hvidovre

Hvidovre, Capital Region Denmark, Denmark

Department of Gastroenterology & Hepatology, Aalborg University Hospital

Aalborg, Denmark

Abdominal Centre, Bispebjerg University Hospital

Copenhagen, Denmark

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