Low-Dose Radiotherapy in Treating Painful Bone Metastases in Patients With Multiple Myeloma

This study is testing whether low-dose radiation — smaller doses than typically used — can effectively relieve pain caused by bone damage from multiple myeloma (a blood cancer that can damage bones), with the goal of reducing side effects while still controlling pain. **You may be eligible if...** - You have been diagnosed with multiple myeloma - You have a painful bone lesion (a specific area of bone damage that shows up on imaging) related to your disease - You are experiencing significant pain in that area (scoring 2 or higher on a standard pain scale) - You are in reasonably good health (ECOG 0–2) - You may have received any number of prior chemotherapy or immunotherapy treatments **You may NOT be eligible if...** - The specific painful bone area has already been treated with radiation or surgery - The bone is fractured or at risk of fracturing, or is being planned for surgical stabilization - There is evidence of spinal cord compression at the treatment site - You have an impending fracture or signs of nerve compression in that area Talk to your doctor to see if this trial is right for you.