Cognitive Decline Clinical Trials

147 recruitingLast updated: June 17, 2026

There are 147 actively recruiting cognitive decline clinical trials across 30 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1, Phase 4. Top locations include Toronto, Ontario, Canada, Boston, Massachusetts, United States, Islamabad, Pakistan. Updated daily from ClinicalTrials.gov.


Cognitive Decline Trials at a Glance

147 actively recruiting trials for cognitive decline are listed on ClinicalTrialsFinder across 6 cities in 30 countries. The largest study group is Not Applicable with 83 trials, with the heaviest enrollment activity in Toronto, Boston, and Islamabad. Lead sponsors running cognitive decline studies include Massachusetts General Hospital, Indiana University, and Foundation University Islamabad.

Browse cognitive decline trials by phase

Treatments under study

About Cognitive Decline Clinical Trials

Looking for clinical trials for Cognitive Decline? There are currently 103 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Cognitive Decline trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Cognitive Decline clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 147 trials

Recruiting
Not Applicable

Evaluating Health Outcomes of AI-Based Fitness Wearables and App Programs in Older Adults Living Alone With Cognitive Decline

Older AdultsPhysical InactivityPhysical Activity+4 more
The University of Tennessee, Knoxville64 enrolled2 locationsNCT07207993
Recruiting
Not Applicable

Polyphenols and Cognitive Decline

Cognitive DysfunctionCognitive Decline
University of California, Los Angeles300 enrolled1 locationNCT06507254
Recruiting
Not Applicable

Exercise Adherence and Cognitive Decline: Phase 2

Cognitive Decline
University of Colorado, Boulder226 enrolled2 locationsNCT07127965
Recruiting
Not Applicable

Community-Based Social Connection Intervention Program to Improve Cardiovascular and Brain Health

Cognitive DeclineStrokeLoneliness+1 more
Universidad de Especialidades Espiritu Santo500 enrolled1 locationNCT07319663
Recruiting
Phase 2

Biomarker-based Trial of NPC-1 for Alzheimer's Pathology

Alzheimer DiseaseMild Cognitive Impairment (MCI)Subjective Cognitive Decline (SCD)
Massachusetts General Hospital40 enrolled1 locationNCT07236190
Recruiting

InRAD Observational Study

Mild Cognitive Impairment (MCI)Alzheimer's Disease(AD)Subjective Cognitive Decline (SCD)+1 more
Stichting International Registry for Alzheimer's Disease and other Dementias Foundation50,000 enrolled2 locationsNCT07213700
Recruiting
Early Phase 1

Attentional Mechanisms in SCD

Subjective Cognitive Decline
Vanderbilt University Medical Center80 enrolled1 locationNCT06002477
Recruiting
Not Applicable

Assessing the Influence of Habitual Beef Intake on Key Molecular Markers of Brain Health

Cardiometabolic healthHealthy AgingBrain Health+2 more
South Dakota State University20 enrolled1 locationNCT07623785
Recruiting

Effects of Comprehensive Community Support Programs on Cognitive Function and Quality of Life in Older Adults

Quality of LifeCognitive DeclineAging
Istanbul Medipol University Hospital120 enrolled1 locationNCT07610109
Recruiting

Identification of Epigenetic Risk Factors for Ischemic Complication During the TAVR Procedure in the Elderly

Cognitive DeclineStroke
University Hospital, Lille542 enrolled1 locationNCT02972008
Recruiting

Cognitive Status After Removal of Skull Base Meningioma

Cognitive ImpairmentCognitive DeclineMeningioma+4 more
Ohio State University50 enrolled1 locationNCT04635657
Recruiting
Not Applicable

Cardiac-Control Affecting Learning Through Mindfulness (CALM)

Age-related Cognitive DeclineAlzheimer Disease
University of Southern California240 enrolled1 locationNCT06410157
Recruiting
Not Applicable

Feasibility and Adherence to a Technology-assisted Home-based Strength Training Program in Adults With Type 2 Diabetes Mellitus and Mild Cognitive Impairment

Age-related Cognitive DeclineMild Cognitive ImpairmentType2diabetes
The University of Texas Medical Branch, Galveston20 enrolled1 locationNCT07416799
Recruiting
Not Applicable

Increasing Physical Activity Through Social Support and Stress Resilience

Sedentary BehaviorHealthySubjective Cognitive Decline (SCD)+1 more
Arizona State University86 enrolled1 locationNCT06896825
Recruiting
Not Applicable

Effect of Hypoxic Conditioning on Cerebrovascular Health in the Elderly

ExerciseBrain DiseasesCognitive Decline+4 more
University Hospital, Grenoble64 enrolled1 locationNCT05048680
Recruiting
Phase 2

Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer

Breast CancerBreast Cancer Stage IBreast Cancer Stage II+5 more
UNC Lineberger Comprehensive Cancer Center90 enrolled1 locationNCT06727773
Recruiting
Not Applicable

A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses

Cognitive ImpairmentCognitive DeclineAlzheimer Disease+3 more
Arizona State University216 enrolled1 locationNCT05877196
Recruiting
Not Applicable

δ in Dementia Clinical Trials

DementiaCognitive DeclineAlzheimer's Disease(AD)+1 more
The University of Texas Health Science Center at San Antonio200 enrolled1 locationNCT05592678
Recruiting
Phase 2

Fasudil Trial for Treatment of Early Alzheimer's Disease (FEAD)

Alzheimer DiseaseCognitive Decline, Mild
Helse Stavanger HF200 enrolled6 locationsNCT06362707
Recruiting
Not Applicable

Personalized Digital Training for COGnitive FITness in Mild Cognitive Impairment

Mild Cognitive Impairment (MCI)Subjective Cognitive Decline (SCD)
Giovanna Zamboni100 enrolled2 locationsNCT07286448