Cognitive Decline Clinical Trials

92 recruiting

Cognitive Decline Trials at a Glance

131 actively recruiting trials for cognitive decline are listed on ClinicalTrialsFinder across 6 cities in 26 countries. The largest study group is Not Applicable with 74 trials, with the heaviest enrollment activity in Toronto, Minneapolis, and Chongqing. Lead sponsors running cognitive decline studies include Foundation University Islamabad, Indiana University, and Aristotle University Of Thessaloniki.

Browse cognitive decline trials by phase

Treatments under study

About Cognitive Decline Clinical Trials

Looking for clinical trials for Cognitive Decline? There are currently 92 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Cognitive Decline trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Cognitive Decline clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 131 trials

Recruiting
Not Applicable

Personalized Digital Training for COGnitive FITness in Mild Cognitive Impairment

Mild Cognitive Impairment (MCI)Subjective Cognitive Decline (SCD)
Giovanna Zamboni100 enrolled2 locationsNCT07286448
Recruiting
Not Applicable

MindWalk Intervention for Older South Asian Caregivers of People With Cognitive Disabilities (CD)

Cognitive DeclineStress, Psychological
University of Illinois at Chicago50 enrolled8 locationsNCT06002919
Recruiting
Not Applicable

Increasing Physical Activity Through Social Support and Stress Resilience

Sedentary BehaviorHealthySubjective Cognitive Decline (SCD)+1 more
Arizona State University86 enrolled1 locationNCT06896825
Recruiting
Phase 1Phase 2

FACE Phase II (a Stage II Trial)

MCIMild Behavioral ImpairmentSubjective Cognitive Decline (SCD)
Stanford University80 enrolled1 locationNCT07130669
Recruiting
Not Applicable

Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study

Cognitive ImpairmentCognitive Decline
Ohio State University88 enrolled1 locationNCT06223672
Recruiting

InRAD Observational Study

Mild Cognitive Impairment (MCI)Alzheimer's Disease(AD)Subjective Cognitive Decline (SCD)+1 more
Stichting International Registry for Alzheimer's Disease and other Dementias Foundation50,000 enrolled1 locationNCT07213700
Recruiting
Not Applicable

mPATH for Low-income Older Adults

InsomniaCognitive DeclineSedentary Time
Johns Hopkins University176 enrolled1 locationNCT05935241
Recruiting

Plant-based Diets and Healthy Aging

SarcopeniaCognitive DeclineFrailty+1 more
National Health Research Institutes, Taiwan5,000 enrolled1 locationNCT07151365
Recruiting
Not Applicable

Effects of Real vs. Soundless Acoustic Stimulation During Deep Sleep on Brain Activity, Memory, and Blood Biomarkers in Older Adults (60-85) With Mild Memory Impairment

Cognitive DeclineAlzheimer DiseaseMild Cognitive Impairment (MCI)+2 more
University of Bern60 enrolled1 locationNCT06669546
Recruiting
Not Applicable

Prediction of Cognitive Test Performance Using AI-Based Analysis of Narrative Speech

Mild Cognitive ImpairmentSubjective Cognitive DeclineCognitive Function Assessment
Chang Gung Memorial Hospital150 enrolled1 locationNCT07511270
Recruiting
Not Applicable

Primary Care Detection of Cognitive Impairment Leveraging Health & Consumer Technologies in Underserved Communities: The MyCog Trial

Cognitive ImpairmentDementiaCognitive Decline+1 more
Northwestern University45,257 enrolled1 locationNCT05607732
Recruiting

Lombard Cohort of Brain Health Services

Subjective Cognitive Decline (SCD)Functional Cognitive Disorder
University of Milano Bicocca1,000 enrolled5 locationsNCT07457138
Recruiting
Not Applicable

Enhancing Attention and Wellbeing Using Digital Therapeutics

Cognitive DeclineAgingMCI
University of California, San Francisco4,000 enrolled1 locationNCT06397469
Recruiting
Not Applicable

TMS for Cognitive Decline in Aging and Preclinical AD

Cognitive DeclineHealthy AgingProdromal Alzheimer's Disease+1 more
Massachusetts General Hospital80 enrolled1 locationNCT06956300
Recruiting

TRIAD - Tracking Risk in Integrated Alzheimer's Diagnostics.

Cognitive Decline
Istituti Clinici Scientifici Maugeri SpA80 enrolled1 locationNCT07399418
Recruiting
Not Applicable

Increasing Preoperative Cognitive Reserve to Prevent Postoperative Cognitive Dysfunction in Cardiac Surgical Patients

Postoperative DeliriumPostoperative Cognitive DeclinePostoperative Cognitive Dysfunction
Heart and Brain Research Group, Germany100 enrolled1 locationNCT04493996
Recruiting
Not Applicable

Feasibility and Adherence to a Technology-assisted Home-based Strength Training Program in Adults With Type 2 Diabetes Mellitus and Mild Cognitive Impairment

Age-related Cognitive DeclineMild Cognitive ImpairmentType2diabetes
The University of Texas Medical Branch, Galveston20 enrolled1 locationNCT07416799
Recruiting
Not Applicable

MIND Foods and Aerobic Training in Black Adults With HTN

Aerobic ExerciseHypertensionCognitive Decline+1 more
Indiana University128 enrolled1 locationNCT06152614
Recruiting

The Signature of Alzheimer's Disease in Subjective Cognitive Decline

Subjective Cognitive ImpairmentSubjective Cognitive ConcernsSubjective Cognitive Decline (SCD)+3 more
IRCCS Policlinico S. Donato250 enrolled1 locationNCT07402161
Recruiting
Not Applicable

Cognitive Screening Made Easy for PCPs - Administrative Supplement

Cognitive ImpairmentCognitive DeclineDementia, Mild
University of Texas at Austin100 enrolled3 locationsNCT06928298