RecruitingNot ApplicableNCT03868592
Long-term, Substantial Weight Loss and Insulin Regulation of Lipolysis
Sponsor
Mayo Clinic
Enrollment
30 participants
Start Date
Aug 1, 2019
Study Type
INTERVENTIONAL
Conditions
Summary
It is not known how much improvement in insulin regulated lipolysis (the breakdown of triglycerides) occurs following substantial, sustained weight loss. Researchers will test the effects of inflammation and lipolysis regulation in people before and after bariatric surgery (sleeve gastrectomy) to answer these questions.
Eligibility
Min Age: 18 YearsMax Age: 65 Years
Inclusion Criteria2
- BMI 40 - 50 kg/m2.
- Mo active physical illness that would interfere with mobility or weight loss after bariatric surgery
Exclusion Criteria8
- Type 1 or Type 2 Diabetes diagnosis or fasting plasma glucose ≥126 mg/dL
- Active coronary artery disease
- Participation in structured exercise (\>2 times per week for 30 minutes or longer)
- Smoking
- Medications known to affect adipose tissue metabolism (e.g., beta blockers, corticosteroids)
- Renal insufficiency (serum creatinine \> 1.5mg/dl)
- Chronic active liver disease (Bilirubin \> 17mmol/L, AST \> 144 IU/L, or ALT\>165IU/L)
- Pregnancy or breastfeeding.
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Interventions
PROCEDUREGastric sleeve/bariatric surgery
weight loss
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT03868592
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