Respiratory Support in Chronic Obstructive Pulmonary Disease (COPD) Patients

This study is investigating the best way to support breathing in people with severe COPD (chronic obstructive pulmonary disease) after they have recovered from an episode of breathing failure requiring mechanical ventilation and been taken off the machine. Researchers want to find out whether ongoing home non-invasive ventilation support is beneficial after hospital discharge. **You may be eligible if...** - You have severe COPD with significant airflow obstruction - You were recently hospitalized for a COPD flare-up involving breathing failure that required mechanical ventilation for more than 24 hours - Your breathing and carbon dioxide levels have now stabilized after ventilator removal (stable for 48 hours to 2 weeks) **You may NOT be eligible if...** - You are already on home breathing support devices (NIV or CPAP) - Your breathing problems are primarily caused by obesity, chest wall disease, or non-COPD conditions - You have other serious conditions that prevent participation Talk to your doctor to see if this trial is right for you.