RecruitingNot ApplicableNCT03921931

Retinal Photoreceptor Outer Segment Length Before and After Light Stimulation - a Pilot Study

Assessment of Retinal Photoreceptor Outer Segment Length With Optical Coherence Tomography Before and After Light Stimulation - a Pilot Study

Sponsor

Medical University of Vienna

Enrollment

35 participants

Start Date

Nov 26, 2018

Study Type

INTERVENTIONAL

Conditions

Primary Open Angle Glaucoma Macular Degeneration, Dry

Summary

It has been shown that reactions of human retinal photoreceptors to a light stimulus can be measured with custom-made, research prototype optical coherence tomography (OCT) systems. This can be used as a biomarker for the function of the photoreceptors. Due to the high technical demands on the system, however, the technique is currently not available for clinical purposes. In this pilot study a protocol to measure changes in retinal photoreceptor layer thickness before and after light stimulation shall be developed based on a commercial OCT system and newly developed algorithms. Other variables, such as circadian processes shall be investigated as well. After measurements in healthy volunteers, the protocol is planned to be applied in patients with primary open angle glaucoma (POAG) and age-related macular degeneration (AMD) to test for feasibility of the method in these patient groups.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This pilot study is measuring tiny changes in the light-sensitive cells at the back of the eye (photoreceptors) before and after light exposure using specialized imaging (OCT), in healthy volunteers and people with glaucoma or age-related macular degeneration (AMD). **You may be eligible if...** - You are over 18 years old with a mild glasses prescription (under 3 diopters) - For the healthy group: you have normal eye health - For glaucoma patients: you have confirmed primary open-angle glaucoma with mild vision loss - For AMD patients: you have confirmed dry AMD at stage II or III **You may NOT be eligible if...** - You have eye conditions that would interfere with imaging accuracy - You use medications that increase light sensitivity - You have a condition such as lupus that causes photosensitivity Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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