RecruitingNCT07390890

DSLT for Reducing Medication in Glaucoma

Efficacy of Direct Selective Laser Trabeculoplasty (DSLT) for Reducing Medication Burden in Medically Controlled Patients With Ocular Hypertension or Primary Open Angle Glaucoma

Sponsor

The Eye Institute of West Florida

Enrollment

60 participants

Start Date

Feb 10, 2026

Study Type

OBSERVATIONAL

Conditions

Ocular Hypertension Primary Open Angle Glaucoma

Summary

This is a prospective, single arm, open label study conducted at a single site to evaluate the efficacy of Direct Selective Laser Trabeculoplasty (DSLT) in reducing medication burden in patients with medically controlled ocular hypertension or primary open angle glaucoma. The study will assess the primary endpoint of reduction in medication count at 6 months compared to baseline. Secondary endpoints include IOP reduction compared to baseline (both percentage and absolute), complete success rate (no increase in IOP without medications), proportion of eyes needing medication at 6 months, and any secondary surgical interventions at 6 months post-DSLT. Participants will undergo DSLT with 120 shots, 400 µm spot size, and 1.8mJ fixed energy delivered at the limbus over 2.4 seconds. Follow-up visits will occur at 1 month, 3 months, and 6 months post-procedure, with IOP measured using a calibrated Goldmann tonometer.

Eligibility

Plain Language Summary

Simplified for easier understanding

This trial is studying whether a laser treatment called DSLT (diode selective laser trabeculoplasty) can allow people with glaucoma or high eye pressure to reduce or stop their eye drop medications. Glaucoma is a condition where elevated pressure in the eye can damage the optic nerve and lead to vision loss. **You may be eligible if...** - You are an adult with a diagnosis of glaucoma (primary open-angle glaucoma) or high eye pressure (ocular hypertension) - Your eye pressure is currently controlled (≤21 mmHg) with 1 to 3 prescription eye drops - You are scheduled to undergo DSLT treatment in one or both eyes **You may NOT be eligible if...** - You have previously had glaucoma surgery (e.g., trabeculectomy, laser trabeculoplasty, tube shunt, or minimally invasive glaucoma surgery) - You have had cataract surgery in the past 2 years - You have a secondary form of glaucoma (angle-closure, neovascular, or trauma-related) - You have other significant eye conditions such as advanced cataracts or retinal disease Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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