Primary Open Angle Glaucoma Clinical Trials

33 recruitingLast updated: June 18, 2026

There are 33 actively recruiting primary open angle glaucoma clinical trials across 19 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 4, Phase 1. Top locations include Dallas, Texas, United States, Panama City, Panama, Düsseldorf, Germany. Updated daily from ClinicalTrials.gov.


Primary Open Angle Glaucoma Trials at a Glance

33 actively recruiting trials for primary open angle glaucoma are listed on ClinicalTrialsFinder across 6 cities in 19 countries. The largest study group is Not Applicable with 19 trials, with the heaviest enrollment activity in Dallas, Panama City, and Düsseldorf. Lead sponsors running primary open angle glaucoma studies include Cairo University, Nova Eye, Inc., and Sight Sciences, Inc..

Browse primary open angle glaucoma trials by phase

Treatments under study

About Primary Open Angle Glaucoma Clinical Trials

Looking for clinical trials for Primary Open Angle Glaucoma? There are currently 24 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Primary Open Angle Glaucoma trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Primary Open Angle Glaucoma clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 33 trials

Recruiting
Phase 3

A Study to Assess Adverse Events and Effectiveness of Gel Stent (XEN63) Implantation Using Ab Interno and Ab Externo Approaches in Adult Participants With Glaucoma

Primary Open Angle Glaucoma
AbbVie130 enrolled24 locationsNCT06822738
Recruiting
Not Applicable

Hydrus® Microstent New Enrollment Post-Approval Study

Primary Open Angle Glaucoma
Alcon Research545 enrolled22 locationsNCT04553523
Recruiting

PRESERFLO™ MicroShunt XI Observational PMCF Study With no Control Group

Primary Open Angle Glaucoma
Santen SAS112 enrolled11 locationsNCT07235592
Recruiting
Not Applicable

Additive Efficacy of Physical Activity Program in Hypthyroidism Elder Females With Glaucoma and Fatty Liver Issues

Non-Alcoholic Fatty Liver DiseaseSubclinical hypothyroïdismPrimary Open Angle Glaucoma
Cairo University40 enrolled1 locationNCT07599241
Recruiting
Phase 1Phase 2

GVB-2001 Gene Therapy Via Intracameral Injection for the Treatment of Primary Open Angle Glaucoma

Primary Open Angle Glaucoma (POAG)
IVIEW Therapeutics Inc.6 enrolled1 locationNCT06921317
Recruiting

DSLT for Reducing Medication in Glaucoma

Ocular HypertensionPrimary Open Angle Glaucoma
The Eye Institute of West Florida60 enrolled1 locationNCT07390890
Recruiting
Not Applicable

Transcorneal Electrical Stimulation for the Treatment of Visual Field Defects in Patients With Open-Angle Glaucoma

GlaucomaPrimary Open Angle GlaucomaPseudoexfoliation Glaucoma+2 more
Okuvision GmbH50 enrolled1 locationNCT06682962
Recruiting
Not Applicable

Aqueous Humor and Ocular Tissue Analysis in Glaucoma and Cataract

CataractPrimary Open Angle Glaucoma (POAG)
Military Institute od Medicine National Research Institute40 enrolled2 locationsNCT07462000
Recruiting

UBM Evaluation After Combined Deep Sclerectomy With Trabeculotomy in Primary Open Angle Glaucoma

Primary Open Angle Glaucoma (POAG)
Minia University Hospital30 enrolled1 locationNCT07454447
Recruiting
Not Applicable

Glaucoma Respsosne to Lifestyle Corrections in Sleep Apnea

ObesityObstructive Sleep ApneaPrimary Open Angle Glaucoma
Cairo University40 enrolled1 locationNCT07447011
Recruiting
Not Applicable

Clinical Study Evaluating the Safety and Performance of the MIST Device for Intraocular Pressure Reduction in Patients With Primary Open-Angle Glaucoma

Primary Open Angle Glaucoma
Hexiris Inc25 enrolled5 locationsNCT07358650
Recruiting
Not Applicable

Evaluation of BRUDYGLAUCO (DHA + Citicoline) in Patients With Glaucoma

GlaucomaPrimary Open Angle Glaucoma (POAG)Neuroprotection
Institut Catala de Retina108 enrolled2 locationsNCT07322965
Recruiting
Not Applicable

OMNI 3.1 Surgical System in Subjects With Primary Open-Angle Glaucoma

Primary Open Angle Glaucoma
Sight Sciences, Inc.25 enrolled1 locationNCT06991270
Recruiting
Phase 3

Efficacy and Safety of HUC3-637 in Patients With Primary Open Angle Glaucoma or Ocular Hypertension

Ocular HypertensionPrimary Open Angle Glaucoma (POAG)
Huons Co., Ltd.206 enrolled1 locationNCT07335211
Recruiting
Not Applicable

A Comparative Study of Intraocular Pressure Control Using Selective Laser Trabeculoplasty and Latanoprost as Initial Treatments for Primary Open Angle Glaucoma and Ocular Hypertension in Lagos State University Teaching Hospital

Primary Open Angle Glaucoma or Ocular Hypertension
Lagos State Health Service Commission138 enrolled1 locationNCT07310719
Recruiting
Not Applicable

Direct Selective Laser Trabeculoplasty in Ethnic Chinese Population

Ocular HypertensionPrimary Open Angle GlaucomaNormal Tension Glaucoma
BelkinVision45 enrolled2 locationsNCT05902871
Recruiting

Assessment of Endothelial Glycocalyx in Patients With Primary Open-angle Glaucoma

GlaucomaPrimary Open Angle Glaucoma
Fondation Ophtalmologique Adolphe de Rothschild100 enrolled1 locationNCT05264818
Recruiting

Diagnostic Innovations in Glaucoma Study

MyopiaPrimary Open Angle Glaucoma
University of California, San Diego3,000 enrolled1 locationNCT00221897
Recruiting

Glaucoma, Visual Field Loss, and Their Association With Life Space in Older Adults

Primary Open Angle Glaucoma
University of Alabama at Birmingham100 enrolled1 locationNCT04396002
Recruiting
Not Applicable

Direct Selective Laser Trabeculoplasty (DSLT) for Reducing Eye Pressure in Non-Caucasian Patients With Open Angle Glaucoma

Primary Open Angle Glaucoma (POAG)
Select Eye Care60 enrolled1 locationNCT07147647