RecruitingNot ApplicableNCT03924791

Transforaminal Epidural Injection in Acute Sciatica


Sponsor

C.L.A.Vleggeert-Lankamp

Enrollment

142 participants

Start Date

Jun 1, 2019

Study Type

INTERVENTIONAL

Conditions

Summary

Patients suffering from sciatica are treated conservatively for the first 8 weeks due to the favourable prognosis. This period is preferably extended up to 14-16 weeks after which patients may opt for surgery. However, patients may experience severe discomfort due to pain in the leg which can lead to decreased physical activity and socio-economic problems. An adequate therapy to alleviate symptoms during this period of 'wait-and-see' is lacking. In this study, patients will be randomized to treatment with transforaminal epidural injections or standard oral pain medication.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial, titled "Transforaminal Epidural Injection in Acute Sciatica" (study ID: NCT03924791), is studying whether a targeted epidural steroid injection (injected near the nerve root in the spine through a small opening called the foramen) can effectively relieve the leg pain caused by acute sciatica. Sciatica is a condition where a nerve in the lower back becomes compressed or irritated, often by a herniated disc, causing sharp pain, numbness, or weakness that radiates down the leg. This study compares outcomes between patients who receive the injection and those who do not. The study is open to adults aged 18 and older who have been diagnosed with sciatica by a GP, with moderate to severe leg pain (6 or more on a 10-point scale) and symptoms lasting between 3 and 8 weeks. Patients who are pregnant, have had prior epidural injections, or have had spine surgery are not eligible. You may be eligible if you: - Are 18 years of age or older - Have been diagnosed with sciatica by a GP - Have leg pain of 6 or more out of 10 - Have had symptoms for at least 3 weeks but no more than 8 weeks You may NOT be eligible if you: - Are under 18 years old - Have a condition that prevents you from receiving an epidural injection - Have severe scoliosis - Have received a transforaminal epidural injection in the past 6 months - Have had sciatica surgery at the same or different spinal level within the past year - Are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGLidocaine

In combination with dexamethasone or methylprednisolone acetate

DRUGMethylprednisolone Acetate

In combination with lidocaine

DRUGDexamethasone

In combination with lidocaine


Locations(2)

Spaarne Gasthuis

Haarlem, Netherlands

Spaarne Gasthuis

Hoofddorp, Netherlands

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NCT03924791


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