Sciatica Clinical Trials

16 recruitingLast updated: May 21, 2026

There are 16 actively recruiting sciatica clinical trials across 9 countries. Studies span Not Applicable, Phase 4, Phase 1. Top locations include Madrid, Madrid, Spain, Lahore, Punjab Province, Pakistan, Aventura, Florida, United States. Updated daily from ClinicalTrials.gov.


Sciatica Trials at a Glance

16 actively recruiting trials for sciatica are listed on ClinicalTrialsFinder across 6 cities in 9 countries. The largest study group is Not Applicable with 11 trials, with the heaviest enrollment activity in Madrid, Lahore, and Aventura. Lead sponsors running sciatica studies include Riphah International University, The University of Sydney, and Universidad Complutense de Madrid.

Browse sciatica trials by phase

About Sciatica Clinical Trials

Looking for clinical trials for Sciatica? There are currently 16 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Sciatica trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Sciatica clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 116 of 16 trials

Recruiting
Not Applicable

Immediate and 1-week Efficacy of a Single Session of Sciatic Nerve Electrical Stimulation in the Management of Low-back Related Leg Pain

Sciatica
Universidad Complutense de Madrid88 enrolled1 locationNCT07377357
Recruiting
Not Applicable

Efficacy of Sciatic Nerve Electrical Stimulation and Therapeutic Exercise in the Management of Low-back Related Leg Pain

Sciatica
Universidad Complutense de Madrid88 enrolled1 locationNCT07373808
Recruiting
Not Applicable

FINDISC-Pain, Finnish Discectomy Trial on the Benefits and Harms of Surgery in Patients With Lumbar Disc Herniation

SciaticaLumbar Disc Herniation With Radiculopathy
Helsinki University Central Hospital122 enrolled1 locationNCT07418944
Recruiting
Phase 4

Efficacy of M640 in Acute Lumbosacral Musculoskeletal Conditions.

Lumbar Spinal StenosisSciatica Acute
Primus Pharmaceuticals50 enrolled24 locationsNCT06157177
Recruiting
Not Applicable

Two-leg Rotation and Sciatica

Sciatica Due to Intervertebral Disc Disorder
University of Hail70 enrolled1 locationNCT07444125
Recruiting
Not Applicable

Comparing Ultrasound-Guided Transgluteal Nerve Block to Standard Care

Sciatica Acute
University of California, San Francisco100 enrolled1 locationNCT07397117
Recruiting
Phase 1

Study to Evaluate Safety of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral Radiculopathy

Lumbosacral RadiculopathySciaticaSciatic Radiculopathy+3 more
Consano Bio24 enrolled3 locationsNCT07264270
Recruiting
Not Applicable

A Multicomponent Intervention for Patients With Lumbosacral Radiculopathy: Move-MORE

Lumbosacral RadiculopathySciaticaRadiculopathy Lumbar+2 more
National University of Natural Medicine32 enrolled1 locationNCT07125027
Recruiting
Not Applicable

SNAG and SNME in Non-Specific Sciatic Pain

sciatica painSciatica AcuteMulligan Mobilization
Istinye University30 enrolled1 locationNCT07161323
Recruiting

Total Lumbar Disc Prosthesis and Subsequent Work Activity at at Least Five Years After Total Lumbar Disc Replacement

SciaticaLumbar Disc HerniationLumbar Disc Degeneration+2 more
University of Valencia150 enrolled1 locationNCT06989632
Recruiting
Not Applicable

Comparing the Efficacy of Steroid, Acupuncture and Platelet Rich Plasma Injection in Patients With Sciatica

Sciatica
Taipei Medical University Hospital90 enrolled1 locationNCT03801512
Recruiting
Not Applicable

Effects of SSMC With and Without Myofascial Release in Patients With Sciatica

Sciaticasciatica pain
Riphah International University74 enrolled1 locationNCT06696898
Recruiting
Not Applicable

Effects of Myofacial Release Technique and Sciatic Nerve Slider Technique in Sciatica

SciaticaRange of motionSciatic Neuropathy
Riphah International University36 enrolled1 locationNCT06536829
Recruiting
Phase 4

Duloxetine for chronic sciatica (DREAM): an adaptive randomised placebo-controlled trial

Sciatica
The University of Sydney332 enrolled1 locationACTRN12624000919516
Recruiting
Not Applicable

Transforaminal Epidural Injection in Acute Sciatica

SciaticaSciatica Due to Intervertebral Disc DisorderSciatic Radiculopathy
C.L.A.Vleggeert-Lankamp142 enrolled2 locationsNCT03924791
Recruiting
Phase 4

Oral steroids in sciatica: The OASIS Randomised Controlled Trial

Sciatica
The University of Sydney200 enrolled1 locationACTRN12619001716156