RecruitingPhase 2Phase 3NCT03937661

Autologous Platelet-Rich Plasma Intra-ovarian Infusion in Poor Responders

Investigating Improvement of Ovarian Function Following Autologous PRP Intra-ovarian Infusion in Poor Responders

Sponsor

Genesis Athens Clinic

Enrollment

100 participants

Start Date

May 6, 2019

Study Type

INTERVENTIONAL

Conditions

Ovary; Anomaly Infertility, Female

Summary

Autologous PRP intra ovarian infusion may improve ovarian response, patients' hormonal profile as well as fresh embryo transfer (ET)-ICSI cycles' outcome in patients presenting with Poor Ovarian Response (POR).

Eligibility

Sex: FEMALEMin Age: 35 YearsMax Age: 47 Years

Inclusion Criteria6

Poor Ovarian Response according to Bologna Criteria (fulfilling 2 out of 3 of the following)
Age ≥ 40 years
AMH \< 1.1 ng/ml OR AFC \< 7
≤ 3 oocytes with a conventional stimulation protocol)
Discontinuation of any complementary/adjuvant treatment including hormone replacement, acupuncture, and botanotherapy, for at least three months prior to recruitment.
Willing to comply with study requirements

Exclusion Criteria15

Any pathological disorder related to reproductive system anatomy
Cycle irregularities
Amenorrhea
Endometriosis
Adenomyosis
Fibroids and adhesions
Infections in reproductive system
Current or previous diagnosis of cancer in reproductive system
History of familiar cancer in reproductive system
Severe male factor infertility
Prior referral for PGT
Ovarian inaccessibility -Endocrinological disorders (Hypothalamus-
Pituitary disorders, thyroid dysfunction, diabetes mellitus, metabolic syndrome)
BMI\>30 kg/m2 or BMI\<18.5 kg/m2
Systematic autoimmune disorders