RecruitingNot ApplicableNCT03958240

Deciphering Mechanisms Underlying Cancer Immunogenicity


Sponsor

Institut Claudius Regaud

Enrollment

1,100 participants

Start Date

Jan 17, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

This trial is a translational, open-label, multicentric, prospective cohort study of 1100 patients aiming to describe the PD-1 (programmed death) expression in T cells (T lymphocytes) in different solid tumors. The study will be conducted on a population of patients with local and/or metastatic malignant solid tumor and who are followed within a standard of care procedure or clinical trial. Patients with any of the following tumor types may be enrolled in the trial: * Head and neck cancer, * Ovarian cancer, * Cervical cancer, * Pre-invasive CIN III cervical cancer (Cervical Intra-epithelial Neoplasia III cervical cancer), * Other solid tumor types (including glioblastoma, NSCLC (Non-small cell lung cancer), anal cancer) Each tumor type will be considered as an independent cohort. For each included patient, biological specimen (tumor sample, blood samples and ascites samples if applicable) will be collected. Study participation of each patient will be 5 years.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is collecting tumor tissue and blood samples from patients with various solid cancers to analyze what makes some tumors more visible to the immune system than others (a property called immunogenicity). The findings will help researchers develop better immunotherapy strategies. **You may be eligible if...** - You have a confirmed solid tumor cancer — including head and neck cancer, ovarian, cervical, glioblastoma (brain cancer), non-small cell lung cancer, anal cancer, or others - OR you have a pre-cancerous cervical condition (high-grade dysplasia, CIN II or CIN III) - You are scheduled for surgery, biopsy, or other procedure that allows tumor tissue collection - You are at least 18 years old **You may NOT be eligible if...** - You are unable or unwilling to provide a tissue or blood sample - You are under 18 years old - You have a condition that makes sample collection unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERBlood samples, tumor biopsy specimens and ascites samples will be collected.

Blood samples, tumor biopsy specimens and ascites samples will be collected at different time points (if feasible, according to the samples taken in the standard practice) for a maximum follow-up period of 5 years from baseline: * at Baseline. * at every surgical procedure or tumor biopsy. * every 6 months (± 2 months) (only blood sample). * at the time of the progression or recurrence, additional samples will be collected, and optionally at the time of the following progressions or recurrences (if applicable). For patients undergoing a RT treatment, blood samples will be collected before the RT (i.e. at the time of planning CT-scan), at the last session of RT (± 2 days) and 3 months after the end of the RT (± 2 weeks).


Locations(3)

Hopital Larrey

Toulouse, France

Hopital Rangueil

Toulouse, France

Institut Universitaire du Cancer Toulouse - Oncopole

Toulouse, France

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NCT03958240


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