RecruitingNot ApplicableNCT03983473

Identification of Fecal Microbiota Biomarkers of Spondyloarthritis in Patients Suffering From Crohn's Disease.

Identification of Fecal Microbiota Biomarkers of Spondyloarthritis in Patients Suffering From Crohn's Disease. Identification de Biomarqueurs de SPondylArthrite Chez Les Patients Atteints de Maladie de CROhn présents Dans le MICrobiote fécal.

Sponsor

Central Hospital, Nancy, France

Enrollment

240 participants

Start Date

Nov 16, 2021

Study Type

INTERVENTIONAL

Conditions

Crohn Disease Spondyloarthritis

Summary

The MICROSPA project aims to compare gut microbiota, serum cytokines, and PBMC of patients suffering from Crohn's disease (CD) associated or not to spondylarthritis (SpA). 3 groups of patients will be analyzed: patients suffering from CD alone, patients suffering from SpA alone, patients suffering from CD and SpA. One group of healthy controls will be analysed as a comparator. Fecal microbiota will be determined by bacteriome, virome and fungome NGS sequencing

Eligibility

Min Age: 18 Years

Inclusion Criteria6

Age ≥ 18 years.
Patients will be recruited according to 3 groups:
Patients with Crohn's disease and axial spondyloarthritis according to the criteria below.
Patients with Crohn's disease (MC patients) with a diagnosis established according to clinical, biological criteria, radiological, endoscopic and / or histological studies for 3 months. With diagnosis of exclusion of a spondyloarthritis on criteria ASAS and / or New York modified.
Patients with axial spondyloarthritis (SpA patients) with a diagnosis based on modified ASAS and / or New York criteria with exclusion diagnosis of Crohn's disease.
Patient with the ability to give free and express informed consent.

Exclusion Criteria8

History of colonic resection
Taking antibiotics or colon preparation for colonoscopy within 8 weeks before stool collection (Temporary contraindication = removal possible before colic or first bowel preparation after the start of colonic preparation).
Ostomy at the time of sampling
BMI\> 30
extreme diet
unbalanced diabetes
Pregnant woman
Patient under guardianship, under curatorship or under the protection of justice Contacts/Locations Central Contact