RecruitingNot ApplicableNCT03983473

Identification of Fecal Microbiota Biomarkers of Spondyloarthritis in Patients Suffering From Crohn's Disease.

Identification of Fecal Microbiota Biomarkers of Spondyloarthritis in Patients Suffering From Crohn's Disease. Identification de Biomarqueurs de SPondylArthrite Chez Les Patients Atteints de Maladie de CROhn présents Dans le MICrobiote fécal.


Sponsor

Central Hospital, Nancy, France

Enrollment

240 participants

Start Date

Nov 16, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

The MICROSPA project aims to compare gut microbiota, serum cytokines, and PBMC of patients suffering from Crohn's disease (CD) associated or not to spondylarthritis (SpA). 3 groups of patients will be analyzed: patients suffering from CD alone, patients suffering from SpA alone, patients suffering from CD and SpA. One group of healthy controls will be analysed as a comparator. Fecal microbiota will be determined by bacteriome, virome and fungome NGS sequencing


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study looks for specific patterns in gut bacteria (the microbiome) that may help identify which patients with Crohn's disease also have spondyloarthritis — a type of inflammatory joint disease affecting the spine. Understanding this link could lead to earlier diagnosis and better treatment. **You may be eligible if...** - You are 18 or older - You fall into one of these groups: (1) Crohn's disease with axial spondyloarthritis, (2) Crohn's disease without spondyloarthritis, or (3) axial spondyloarthritis without Crohn's disease - You are able to give informed consent **You may NOT be eligible if...** - You have had part of your colon removed - You have recently taken antibiotics or completed bowel prep - Other specified exclusion criteria apply Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERMicrobiota Sequencing

virome, bacteriome, fungome NGS sequencing


Locations(2)

Central Hospital

Nancy, Lorraine, France

Saint Antoine Hospital

Paris, France

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NCT03983473


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