NIPSA Versus Marginal Approach by Palatal Incision and MIST in Periodontal Regeneration

This study compares two different surgical techniques for treating deep gum (periodontal) bone defects. Periodontitis is a serious gum disease that destroys the bone and tissue supporting your teeth. When a deep pocket forms between the tooth and bone, surgery is often needed to regenerate the lost tissue. This study compares a newer approach called NIPSA (Non-Incised Papillae Surgical Approach) against traditional incision methods combined with minimally invasive techniques, to see which better promotes bone and tissue regeneration. Participants will undergo one of the two surgical procedures and be followed over time with measurements of pocket depth, bone regrowth, and gum tissue healing. Both approaches use regenerative materials to help rebuild the destroyed tissue. You may be eligible if: - You have been diagnosed with periodontitis - Your plaque and bleeding scores are below 30% - You have a pocket depth greater than 5 mm in the affected area - You have an intrabony defect greater than 3 mm involving the buccal (cheek-side) wall You may NOT be eligible if: - You have a systemic disease that contraindicates periodontal surgery - The affected tooth is a third molar (wisdom tooth) - The affected tooth has inadequate root canal treatment or faulty dental restorations Talk to your doctor to see if this trial is right for you.