Periodontal Diseases Clinical Trials

55 recruitingLast updated: June 18, 2026

There are 55 actively recruiting periodontal diseases clinical trials across 25 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 4. Top locations include Izmir, Çiğli, Turkey (Türkiye), Kaohsiung City, Taiwan, Birmingham, Alabama, United States. Updated daily from ClinicalTrials.gov.


Periodontal Diseases Trials at a Glance

55 actively recruiting trials for periodontal diseases are listed on ClinicalTrialsFinder across 6 cities in 25 countries. The largest study group is Not Applicable with 35 trials, with the heaviest enrollment activity in Izmir, Kaohsiung City, and Birmingham. Lead sponsors running periodontal diseases studies include G. d'Annunzio University, Izmir Katip Celebi University, and Universidad de Murcia.

Browse periodontal diseases trials by phase

Treatments under study

About Periodontal Diseases Clinical Trials

Looking for clinical trials for Periodontal Diseases? There are currently 49 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Periodontal Diseases trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Periodontal Diseases clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 55 trials

Recruiting
Not Applicable

The Effect of Vitamin D Supplementation on the Anti-inflammatory Response in Periodontal Diseases

GingivitisPeriodontal DiseasesVitamin D Deficiency
Recep Tayyip Erdogan University Training and Research Hospital120 enrolled1 locationNCT07636733
Recruiting
Not Applicable

Clinical Effectiveness of Biologic Agents as an Adjunct to Non-surgical Periodontal Therapy of Intrabony Defects

Periodontal DiseasesPeriodontal Attachment LossPocket, Periodontal+1 more
G. d'Annunzio University88 enrolled1 locationNCT05858411
Recruiting
Not Applicable

An Evaluation of the Effect of the Erchonia FX-405 Laser as an Adjunctive Treatment of Periodontitis

Gum diseasePeriodontal DiseasesPeriodontitis
Erchonia Corporation70 enrolled2 locationsNCT06656325
Recruiting
Not Applicable

Influence of Finishing Clear Aligner Marginal Termination Design on Subgingival Periodontal Microbiota During Orthodontic Treatment: A Split-Mouth Study.

Periodontal DiseasesOral HealthMalocclusion
George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures39 enrolled1 locationNCT07533058
Recruiting

Association Between Periodontal Status and the Prevalence of Entamoeba Gingivalis and Trichomonas Tenax

PeriodontitisGingivitis and Periodontal Diseases
Abant Izzet Baysal University120 enrolled1 locationNCT07551115
Recruiting

Candida Albicans in Syrian Patients With Periodontitis

Periodontal DiseasesPeriodontitisPeriodontal Disease
Al-Hawash Private University100 enrolled1 locationNCT07574827
Recruiting
Phase 4

Antibiotics as Adjuncts to Periodontal Therapy:Pharmacokinetic Considerations and Dosing Strategies

AntibioticsPeriodontal DiseasesPharmacokinetics
University of Geneva, Switzerland45 enrolled1 locationNCT04669717
Recruiting

Development of A Self-Assessment Tool for Personalized Preventive Periodontal Care Among the Saudi Population Using Semi-Supervised Learning

GingivitisPeriodontal DiseasesPeriodontitis
Universiti Sains Malaysia393 enrolled1 locationNCT07410351
Recruiting

ORAL HYGIENE, PERIODONTAL STATUS AND QUALITY OF LIFE

GingivitisPeriodontal DiseasesPeriodontitis
Abant Izzet Baysal University160 enrolled1 locationNCT07530978
Recruiting

Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis

periodontal inflammationPeriodontal DiseasesPeriodontitis+2 more
University of Chile30 enrolled1 locationNCT07536204
Recruiting
Not Applicable

Evaluation of Toothbrush Bristles

Gingivitis and Periodontal Diseases
State University of New York at Buffalo70 enrolled1 locationNCT07306026
Recruiting
Not Applicable

NOVOSYN® Quick Versus MONOSYN® Quick Suture Material in Resective Periodontal Surgery

GingivitisPeriodontal DiseasesGingival Diseases
Aesculap AG84 enrolled1 locationNCT05813236
Recruiting
Not Applicable

Evaluation Of The Efficacy Of Subgingival Application Of Lovastatin Gel As An Adjunct To Non-Surgical Treatment Of Periodontitis In Generally Healthy Smokers And Non-Smokers Patients in Central Europe.

Periodontal DiseasesPeriodontitisPeriodontal Disease+1 more
Medical University of Silesia44 enrolled1 locationNCT07282756
Recruiting
Not Applicable

Periodontal Granulation Tissue Preservation in Surgical Periodontitis Treatment

Periodontal DiseasesPeriodontal PocketPeriodontal Bone Loss
Universidad de Murcia25 enrolled1 locationNCT05533528
Recruiting
Not Applicable

NIPSA Versus Marginal Approach by Palatal Incision and MIST in Periodontal Regeneration

Periodontal DiseasesPeriodontitisPeriodontal Pocket
Universidad de Murcia60 enrolled1 locationNCT03997552
Recruiting
Not Applicable

Effectiveness of Intraseptal Anesthesia for Periodontal Surgical Procedures

PeriodontitisGingivitis and Periodontal Diseases
University of Belgrade60 enrolled1 locationNCT07212270
Recruiting

Periodontal Status and Disease Severity in Pemphigus Vulgaris Patients

Periodontal DiseasesPemphigus Vulgaris (PV)
Saglik Bilimleri Universitesi20 enrolled1 locationNCT07384221
Recruiting
Not Applicable

F.L.O.S.S. Project (Facilitated Lessons on Oral and Systemic Health in Survivors)

CancerOral MucositisPeriodontal Diseases
Georgetown University100 enrolled1 locationNCT06315855
Recruiting

HALP Score, Blood-Based Inflammatory Indices, and Salivary MMP-8 in Periodontal Disease and Healing After Non-Surgical Therapy

Periodontal DiseasesPeriodontitisGingivitis; Chronic
Ömer Faruk Okumuş180 enrolled1 locationNCT07312045
Recruiting
Not Applicable

Periodontal Health and Sodium Bicarbonate Toothpaste

Periodontal Diseases
University of Plymouth100 enrolled1 locationNCT07274189