Phenotyping Genetic Risk for Type 2 Diabetes

This study is examining how genetic risk factors translate into physical differences in metabolism — specifically glucose and insulin responses — in people at elevated genetic risk for type 2 diabetes. The goal is to identify who is at highest risk before they develop the disease. **You may be eligible if...** - You are between 10 and 70 years old - You previously participated in the UPenn Biobank or Center for Applied Genomics Biobank and agreed to be re-contacted - Adults must have a BMI of 25 or higher; children and adolescents must have a BMI at or above the 85th percentile **You may NOT be eligible if...** - You already have a diagnosis of type 1, type 2, or any other form of diabetes - You take medications that affect blood sugar (such as metformin, steroids, or other diabetes drugs) - You are pregnant - You have anemia, gastrointestinal problems affecting absorption, or another serious medical condition - You recently received chemotherapy Talk to your doctor to see if this trial is right for you.