RecruitingNCT04066465

Neurocognitive Function After Proton Therapy in Children and Adolescents

Neurocognitive Function /executive Functions After Proton Therapy in Children and Adolescents.


Sponsor

Technische Universität Dresden

Enrollment

90 participants

Start Date

Sep 1, 2019

Study Type

OBSERVATIONAL

Conditions

Summary

Brain tumors are the second most frequent malignant diseases in children and adolescents. In the study the short and medium term consequences of proton therapy on cognitive processes in particular on executive functions in pediatric patients shall be highlighted/analysed/evalutated. In a second step, these results are to be compared with 1. a group of children and adolescents who had only /exclusively had operative therapy and 2. with a healthy control group. Thus, the extent to which these treatment options differ in terms of their short and medium-term effect is assessed. Methods of neurocognitive/neurophysiology brain research approaches are applied that may potentially visualize even small / subtle changes in mental activities/neurocognitive function. Therefore the effects of treatment can be evaluated and the neuropsychological outcome of children and adolescents with brain tumors can be improved.


Eligibility

Min Age: 8 YearsMax Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is examining how proton therapy (a precise form of radiation) affects brain function in children and teenagers being treated for brain tumors. Researchers will track memory, attention, thinking, and learning over time to better understand and minimize the effects of radiation on developing brains. **You may be eligible if...** - You are between 8 and 18 years old - You have been diagnosed with a primary brain tumor - You have not previously had radiation to the brain - Your vision and hearing are not significantly impaired - You are able to complete repeated thinking and memory tests (about 1 hour each) - You are able to attend follow-up visits - A parent or guardian has provided written consent **You may NOT be eligible if...** - You have had prior brain radiation - You have significant vision or hearing impairment that would prevent testing - You are unable to attend required follow-up appointments Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(3)

University Hospital Carl GUstav Carus Dresden, Child and adolescent psychiatry and psychotherapy

Dresden, Saxony, Germany

University Hospital Carl GUstav Carus Dresden, Department of Neuropaediatrics

Dresden, Saxony, Germany

University Hospital Carl GUstav Carus Dresden, Department of Radiation Therapy and Radiation Oncology

Dresden, Saxony, Germany

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NCT04066465


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