Optimizing Pain Control in Transurethral Resection of the Prostate

This study looks at the best way to manage pain after transurethral resection of the prostate (TURP) — a surgery to remove excess prostate tissue. The goal is to optimize pain control while minimizing opioid use after the procedure. You may be eligible if: - You are a male patient 18 years or older - You have been identified as a candidate for TURP surgery - You are proficient in English You may NOT be eligible if: - You filled an opioid prescription in the last 2 months - You have an allergy to a medication in the study protocol - You have had pelvic radiation - You have kidney failure, peptic ulcer disease, gastric bypass history, or cirrhosis (which would prevent use of NSAIDs) - You have liver failure, hepatitis, or alcohol abuse (which would prevent use of acetaminophen) Talk to your doctor to see if this trial is right for you.