p16+ Oropharyngeal Cancer Radiation Optimization Trial Reducing Elective Treatment Volumes (PROTEcT)

This study is testing whether a targeted radiation approach — treating only the visible tumour and affected lymph nodes rather than a broader area — is safe and effective for a specific type of throat cancer (HPV-related oropharyngeal cancer). The goal is to reduce side effects while still curing the cancer. **You may be eligible if...** - You are 18 years old or older - You have been diagnosed with HPV-related (p16-positive) squamous cell carcinoma of the throat (oropharynx) - Your cancer is stage T1–T3 with limited lymph node involvement - You are being treated with the intent to cure - Your blood counts, liver, and kidney function are adequate for chemotherapy **You may NOT be eligible if...** - Your cancer has spread to distant parts of the body - You have had previous head and neck radiation at any time - You have had head and neck cancer in the last 5 years - You are pregnant or breastfeeding - Your cancer has spread into the oral cavity Talk to your doctor to see if this trial is right for you.