RecruitingPhase 2NCT04107077

Phase II Study of the Effects of Laparoscopic Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Patients With Advanced Gastric Cancer

A Phase IIa Study of Laparoscopic Hyperthermic Intraperitoneal Chemotherapy (HIPEC) and PD-L1 Expression in Gastric Cancer With Peritoneal Metastases


Sponsor

University of Chicago

Enrollment

21 participants

Start Date

Sep 9, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

To assess if PD-L1 expression can be upregulated in peritoneal metastases from gastric cancer after the administration of HIPEC with greater frequency compared to systemic chemotherapy alone


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a procedure called HIPEC (heated chemotherapy delivered directly into the belly cavity during a minimally invasive surgery) in patients with advanced stomach cancer that has spread to the lining of the abdomen (called peritoneal metastases). The goal is to see if this approach can help control the cancer. **You may be eligible if...** - You have been diagnosed with stomach cancer that has spread to the lining of the abdominal cavity, confirmed by biopsy - You have already completed 2 to 4 months of chemotherapy - You are 18 years old or older - You are reasonably active (ECOG 0–2) - Your blood counts and organ function are adequate **You may NOT be eligible if...** - Your cancer has spread beyond the abdominal lining to other distant organs - You have uncontrolled infections (HIV, hepatitis B or C) - You are younger than 18 (children are excluded from this study) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGCisplatin

Laparoscopic HIPEC will be performed at a maximum of two (2) times spaced approximately 6 weeks apart. The dosing of the drugs will be the same during each administration but adjusted if needed based on lab work. The typical dosages are 200mg of Cisplatin

DRUGMitomycin

Laparoscopic HIPEC will be performed at a maximum of two (2) times spaced approximately 6 weeks apart. The dosing of the drugs will be the same during each administration but adjusted if needed based on lab work. The typical dosages are 30mg of Mitomycin C.


Locations(1)

University of Chicago

Chicago, Illinois, United States

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NCT04107077


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